ArticleAcademic radiology2017
Estimation of Observer Performance for Reduced Radiation Dose Levels in CT: Eliminating Reduced Dose Levels That Are Too Low Is the First Step.
Article in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Agreement of axial T2-MRI versus Contrast-Enhanced CT for solid renal mass active surveillance.Abdominal radiology (New York) · 2026Article
- Reading, Fast and Slow: Characterizing Radiologists' Visual Search Through Abdominal CT for Detecting Hepatic Metastases.Academic radiology · 2026Article
- The Uncoupling of CT Dose and Noise.Radiology · 2026Article
- Insertion of hepatic lesions into clinical photon-counting-detector CT projection data.Physics in medicine and biology · 2025Article
- Physics-informed model-based generative neural network for synthesizing scanner- and algorithm-specific low-dose CT exams.Medical physics · 2025Article
- Radiation Dose Reduction in Cancer Imaging with New-Model CT Scanners: A Quality of Care Evaluation.Cancers · 2025Article
- State-of-the-Art Deep Learning CT Reconstruction Algorithms in Abdominal Imaging.Radiographics : a review publication of the Radiological Society of North America, Inc · 2024Review
- Development and validation of a noise insertion algorithm for photon-counting-detector CT.Medical physics · 2024Article
- Impact of Simulated Reduced-Dose Chest CT on Diagnosing Pulmonary T1 Tumors and Patient Management.Diagnostics (Basel, Switzerland) · 2024Article
- Targeted Training Reduces Search Errors but Not Classification Errors for Hepatic Metastasis Detection at Contrast-Enhanced CT.Academic radiology · 2024Article
- Article
- Milestones in CT: Past, Present, and Future.Radiology · 2023Review
- Synthetic high-energy computed tomography image via a Wasserstein generative adversarial network with the convolutional block attention module.Quantitative imaging in medicine and surgery · 2023Article
- Image-quality characteristics in the longitudinal direction from different image-reconstruction algorithms during single-rotation volume acquisition on head computed tomography: A phantom study.Acta radiologica open · 2023Article
- Is it possible to use low-dose deep learning reconstruction for the detection of liver metastases on CT routinely?European radiology · 2023Article
- Radiation dose in CT-based active surveillance of small renal masses may be reduced by 75%: A retrospective exploratory multiobserver study.Research in diagnostic and interventional imaging · 2023Article
- Understanding Reader Variability: A 25-Radiologist Study on Liver Metastasis Detection at CT.Radiology · 2023Observational
- A training program to reduce reader search errors for liver metastasis detection in CT.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Assessment of task-based image quality for abdominal CT protocols linked with national diagnostic reference levels.European radiology · 2022Article
- GaN Heterostructures as Innovative X-ray Imaging Sensors-Change of Paradigm.Micromachines · 2022Review
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Authors and funding
20 authors.
Funding
Abstract
RATIONALE AND
objectivesThis study aims to estimate observer performance for a range of dose levels for common computed tomography (CT) examinations (detection of liver metastases or pulmonary nodules, and cause of neurologic deficit) to prioritize noninferior dose levels for further analysis. MATERIALS AND
methodsUsing CT data from 131 examinations (abdominal CT, 44; chest CT, 44; head CT, 43), CT images corresponding to 4%-100% of the routine clinical dose were reconstructed with filtered back projection or iterative reconstruction. Radiologists evaluated CT images, marking specified targets, providing confidence scores, and grading image quality. Noninferiority was assessed using reference standards, reader agreement rules, and jackknife alternative free-response receiver operating characteristic figures of merit. Reader agreement required that a majority of readers at lower dose identify target lesions seen by the majority of readers at routine dose.
resultsReader agreement identified dose levels lower than 50% and 4% to have inadequate performance for detection of hepatic metastases and pulmonary nodules, respectively, but could not exclude any low dose levels for head CT. Estimated differences in jackknife alternative free-response receiver operating characteristic figures of merit between routine and lower dose configurations found that only the lowest dose configurations tested (ie, 30%, 4%, and 10% of routine dose levels for abdominal, chest, and head CT examinations, respectively) did not meet criteria for noninferiority. At lower doses, subjective image quality declined before observer performance. Iterative reconstruction was only beneficial when filtered back projection did not result in noninferior performance.
conclusionOpportunity exists for substantial radiation dose reduction using existing CT technology for common diagnostic tasks.
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