ArticleNeuron2017
The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.
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Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75citing papers in PubMed
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Who cites it
75 citing papers in PubMed.
- AAV-mediated age- and circuit-dependent restoration of photoreceptor synaptic structure and function in α2δ4-associated retinal synaptopathy.bioRxiv : the preprint server for biology · 2026Article
- Ankyrin-B and ankyrin-G are required for synaptic integrity in the mouse outer retina.PNAS nexus · 2026Article
- Article
- N-Glycosylation of mGluR6 Modulates Receptor Cell-Surface Transport, G-Protein Coupling, and Interactions With Synaptic Adhesion Molecules.Journal of molecular neuroscience : MN · 2026Article
- Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.Cell death & disease · 2026Article
- Intrafamilial variability of phenotype in CACNA2D4-associated retinal dysfunction: more or less.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Exploring the potential for gene therapy in Cav1.4-related retinal channelopathies.Channels (Austin, Tex.) · 2025Review
- Trans-synaptic Interaction with mGluR6 Contributes to ELFN1 Presynaptic Enrichment in Rod Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dhdds T206A and Dhdds K42E knock-in mouse models of retinitis pigmentosa 59 are phenotypically similar.Disease models & mechanisms · 2025Article
- Presynaptic αNeuron · 2025Article
- Distinct autoregulatory roles of ELFN1 intracellular and extracellular domains on membrane trafficking, synaptic localization, and dimerization.The Journal of biological chemistry · 2025Article
- Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch.PloS one · 2025Article
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic CaCells · 2024Article
- Structural and temporal dynamics analysis of neural circuit from 2002 to 2022: A bibliometric analysis.Heliyon · 2024Review
- LRIT3 expression in cone photoreceptors restores post-synaptic bipolar cell signalplex assembly and partial function iniScience · 2023Article
- Photoreceptor Ion Channels in Signaling and Disease.Advances in experimental medicine and biology · 2023Article
- Identification of candidate genes for developmental colour agnosia in a single unique family.PloS one · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Yuchen WangDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Katherine E FehlhaberJules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ignacio SarriaDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Yan CaoDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Norianne T IngramJules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Debbie Guerrero-GivenElectron Microscopy Core Facility, Max Planck Florida Institute, 1 Max Planck Way, Jupiter, FL 33458, USA.
Ben ThroeschDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92121, USA.
Kristin BaldwinDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92121, USA.
Naomi KamasawaElectron Microscopy Core Facility, Max Planck Florida Institute, 1 Max Planck Way, Jupiter, FL 33458, USA.
Toshihisa OhtsukaDepartment of Biochemistry, University of Yamanashi, Yamanashi 409-3898, Japan.
Alapakkam P SampathJules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kirill A MartemyanovDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: kirill@scripps.edu.
Funding
Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8MRegulation of Signaling in the Retina by RGS ProteinsR01EY018139 · NEI · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2007 to 2025
$8.9MVision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7MMolecular Basis of Photoreceptor WiringR01EY028033 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov, Alapakkam P Sampath · 2017 to 2026
$4.6MFunctional characteristics of rod pathways in the retinaR01EY017606 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SAMPATH, ALAPAKKAM P · 2006 to 2015
$3.7MGenome-wide investigation of somatic mutation in the developing and aging brainR01MH102698 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY, HALL, IRA M · 2014 to 2018
$3.4MAnalyses of retinal circuits after rod rescue in a mouse model of human blindnessR01EY027193 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JEANNIE, FIELD, GREGORY DARIN · 2016 to 2020
$2.7MThe architecture and development of a sensory processing circuit for smellR01DC012592 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY · 2012 to 2016
$2.3MMolecular Basis of RGS Protein Function in the StriatumK02DA026405 · NIDA · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2009 to 2019
$1.2MNEI NIH HHS P30 EY000331NEI NIH HHS R01 EY017606NEI NIH HHS R01 EY018139NEI NIH HHS R01 EY027193NEI NIH HHS R01 EY028033NEI NIH HHS T32 EY007026NIDA NIH HHS K02 DA026405NIDCD NIH HHS R01 DC012592NIMH NIH HHS R01 MH102698
Abstract
Neural circuit wiring relies on selective synapse formation whereby a presynaptic release apparatus is matched with its cognate postsynaptic machinery. At metabotropic synapses, the molecular mechanisms underlying this process are poorly understood. In the mammalian retina, rod photoreceptors form selective contacts with rod ON-bipolar cells by aligning the presynaptic voltage-gated Ca
Indexed as
AnimalsAxonsCalcium ChannelsCalcium Channels, L-TypeCells, CulturedFemaleHumansMaleMiceMice, KnockoutMice, Mutant StrainsNerve Tissue ProteinsReceptors, Metabotropic GlutamateRetinal Bipolar CellsRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsCacna1f protein, mouseCacna2d4 protein, mouseCalcium ChannelsCalcium Channels, L-Typeextracellular leucine-rich repeat fibronectin containing 1 protein, mousemetabotropic glutamate receptor 6Nerve Tissue ProteinsReceptors, Metabotropic Glutamatecalcium channelscell adhesioncircuit formationretinaribbon synapsesynaptic transmissionsynaptogenesistrans-synaptic interactionsvisionwiring
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.