Evidence map›Paper›PMID 28262351›Full record

ArticleCell2017

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Nissan Yissachar, Yan Zhou, Lloyd Ung, Nicole Y Lai, James F Mohan, Allen Ehrlicher, David A Weitz, Dennis L Kasper, Isaac M Chiu, Diane Mathis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Neuroimmune Circuits in Allergic Diseases.Annual review of immunology · 2025
    Review
  13. Imaging the enteric nervous system.Frontiers in neuroanatomy · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nissan YissacharDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Yan ZhouDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Lloyd UngSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Nicole Y LaiDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
James F MohanDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Allen EhrlicherSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
David A WeitzSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Dennis L KasperDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Isaac M ChiuDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: isaac_chiu@hms.harvard.edu.
Diane MathisDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: cbdm@hms.harvard.edu.
Christophe BenoistDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: cbdm@hms.harvard.edu.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Naive T cell homeostasis: Treg selection and survivalR37AI051530 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2009 to 2018
$4.1M
Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host MicrobiotaDP2AT009499 · NCCIH · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2016 to 2019
$2.7M
Naive T cell survival: TCR and IL-7R signal interplayR01AI051530 · NIAID · JOSLIN DIABETES CENTER · PI BENOIST, CHRISTOPHE O. · 2002 to 2009
$2.4M
The role of nociceptor neurons in bacterial host defense and inflammationK22AI114810 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2015 to 2016
$270k
NCCIH NIH HHS DP2 AT009499NIAID NIH HHS K22 AI114810NIAID NIH HHS R01 AI051530NIAID NIH HHS R37 AI051530NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Investigation of host-environment interactions in the gut would benefit from a culture system that maintained tissue architecture yet allowed tight experimental control. We devised a microfabricated organ culture system that viably preserves the normal multicellular composition of the mouse intestine, with luminal flow to control perturbations (e.g., microbes, drugs). It enables studying short-term responses of diverse gut components (immune, neuronal, etc.). We focused on the early response to bacteria that induce either Th17 or RORg

Indexed as

Organ Culture TechniquesAnimalsClostridiumIntestinesMiceSymbiosisenteric nervous systemgut microbiotaneuropeptidesregulatory T cellssubstance P

Identifiers

PMID28262351
PMCPMC5396461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.