Evidence map›Paper›PMID 28262096›Full record

ArticleeLife2017

Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.

Ruchira Sharma, Yoshiro Ishimaru, Ian Davison, Kentaro Ikegami, Ming-Shan Chien, Helena You, Quiyi Chi, Momoka Kubota, Masafumi Yohda, Michael Ehlers and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Identifying Key Regulators in Odorant Receptor Trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Article
  19. Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ruchira SharmaDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0002-2795-7457
Yoshiro IshimaruDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Ian DavisonDepartment of Biology, Boston University, Boston, United States.ORCID 0000-0003-0998-7676
Kentaro IkegamiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Ming-Shan ChienDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Helena YouDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Quiyi ChiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Momoka KubotaDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Masafumi YohdaTokyo University of Agriculture and Technology, Tokyo, Japan.
Michael EhlersDepartment of Neurobiology, Duke University Medical Center, Durham, United States.
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0002-8850-2608
Duke University · USBiogen (United States) · USBoston University · US

Funding

Peripheral Odor Coding in MammalsR01DC014423 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2015 to 2019
$2.3M
Modulation of Odorant Receptor FunctionR01DC012095 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2012 to 2016
$1.8M
NIDCD NIH HHS R01 DC012095NIDCD NIH HHS R01 DC014423
6 · The paper itself

Abstract

Each of the olfactory sensory neurons (OSNs) chooses to express a single G protein-coupled olfactory receptor (OR) from a pool of hundreds. Here, we show the receptor transporting protein (RTP) family members play a dual role in both normal OR trafficking and determining OR gene choice probabilities.

Indexed as

Gene Expression RegulationAnimalsCarrier ProteinsMice, KnockoutModels, BiologicalReceptors, OdorantCarrier ProteinsReceptors, Odorantcell biologychaperoneepigeneticgene regulationGPCRmouseneuroscienceodorantolfactionunfolded protein responseUPR

Identifiers

PMID28262096
PMCPMC5362263
OpenAlexW2591915107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.