ArticleeLife2017
Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Rhizoxin and 2,4-diacetylphloroglucinol contribute to biocontrol ofMicrobiology spectrum · 2026Article
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- GacA uses two distinct regulatory mechanisms to control the biosynthesis of 2,4-diacetylphloroglucinol inApplied and environmental microbiology · 2025Article
- Crystal structures and low-affinity complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway.Bioscience reports · 2025Article
- Polyyne production is regulated by the transcriptional regulators PgnC and GacA inApplied and environmental microbiology · 2025Article
- Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution.mSystems · 2025Review
- Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities ofMicrobiology spectrum · 2025Article
- Metabolites limiting predator growth wane with prey biodiversity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic Insights intoInternational journal of molecular sciences · 2024Article
- Use ofPlants (Basel, Switzerland) · 2024Article
- Resistance towards and biotransformation of a Pseudomonas-produced secondary metabolite during community invasion.The ISME journal · 2024Article
- Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strainSynthetic and systems biotechnology · 2023Article
- Relation of pest insect-killing and soilborne pathogen-inhibition abilities to species diversification in environmental Pseudomonas protegens.The ISME journal · 2023Article
- Exopolysaccharide is required for motility, stress tolerance, and plant colonization by the endophytic bacteriumFrontiers in microbiology · 2023Article
- Sequential interspecies interactions affect production of antimicrobial secondary metabolites in Pseudomonas protegens DTU9.1.The ISME journal · 2022Article
- Identification and Characterization of Bacteria-Derived Antibiotics for the Biological Control of Pea Aphanomyces Root Rot.Microorganisms · 2022Article
- Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.Microbial biotechnology · 2022Review
- Pyoluteorin Produced by the Biocontrol AgentPathogens (Basel, Switzerland) · 2022Article
- Effects of Phosphonate Herbicides on the Secretions of Plant-Beneficial Compounds by Two Plant Growth-Promoting Soil Bacteria: A Metabolomics Investigation.ACS environmental Au · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic co-regulation between biosynthetic pathways for secondary metabolites is common in microbes and can play an important role in microbial interactions. Here, we describe a novel mechanism of metabolic co-regulation in which an intermediate in one pathway is converted into signals that activate a second pathway. Our study focused on the co-regulation of 2,4-diacetylphloroglucinol (DAPG) and pyoluteorin, two antimicrobial metabolites produced by the soil bacterium
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.