Evidence map›Paper›PMID 28262033›Full record

ArticlePharmaceutical biology2017

Fatty acid composition and anticancer activity in colon carcinoma cell lines of Prunus dulcis seed oil.

Filiz Mericli, Eda Becer, Hilal Kabadayı, Azmi Hanoglu, Duygu Yigit Hanoglu, Dudu Ozkum Yavuz, Temel Ozek, Seda Vatansever

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06887673 (Exploring the Impact of Montelukast, SPM, and/or Almond/Almond Oil Supplementation on Lipid Mediator Biosynthesis in Colorectal, Sarcomas, Brain Tumors, Endometrial, and Ovarian Cancer), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06887673 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Exploring the Impact of Montelukast, SPM, and/or Almond/Almond Oil Supplementation on Lipid Mediator Biosynthesis in Colorectal, Sarcomas, Brain Tumors, Endometrial, and Ovarian Cancer: A Pilot Study

TypeinterventionalSponsorUniversity of South FloridaRan2025 to 2026Enrolled56ConditionsColorectal Cancer, Sarcoma, Brain Tumors, Endometrial CancerArmsNo Interventions, Sports Pro Resolve 4 g, Double Wood SPM 4 g, 20 California Sweet Almonds, Montelukast 10 Mg Oral Tablet
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Article
  7. Phytochemical Profiling and Biological Potential ofPlants (Basel, Switzerland) · 2023
    Article
  8. Diosgenin and Monohydroxy Spirostanol fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Review
  11. Evaluation of Marketed Almond Oils [Turkish journal of pharmaceutical sciences · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Oleuropein-Laded Ufasomes Improve the Nutraceutical Efficacy.Nanomaterials (Basel, Switzerland) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Filiz Mericlia Department of Pharmacognosy-Phytotherapy, Faculty of Pharmacy , Near East University , Mersin , Turkey.
Eda Becerb Department of Biochemistry, Faculty of Pharmacy , Near East University , Mersin , Turkey.
Hilal Kabadayıc Department of Histology and Embryology, Faculty of Medicine , Celal Bayar University , Manisa , Turkey.
Azmi Hanoglud Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University , Mersin , Turkey.
Duygu Yigit Hanoglud Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University , Mersin , Turkey.
Dudu Ozkum Yavuzd Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University , Mersin , Turkey.
Temel Ozeke Department of Pharmacognosy, Faculty of Pharmacy , Anadolu University , Eskisehir , Turkey.
Seda Vatanseverc Department of Histology and Embryology, Faculty of Medicine , Celal Bayar University , Manisa , Turkey.
Mersin Üniversitesi · TRNear East University · CYAnadolu University · TRManisa Celal Bayar University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAlmond oil is used in traditional and complementary therapies for its numerous health benefits due to high unsaturated fatty acids content.

objectivesThis study investigated the composition and in vitro anticancer activity of almond oil from Northern Cyprus and compared with almond oil from Turkey. MATERIALS AND

methodsAlmond oil from Northern Cyprus was obtained by supercritical CO

resultsOleic acid (77.8%; 75.3%), linoleic acid (13.5%; 15.8%), palmitic acid (7.4%; 6.3%), were determined as the major compounds of almond oil from Northern Cyprus and Turkey, respectively. In the MTT assay, both almond oils were found to be active against Colo-320 and Colo-741 cells with 1:1 dilution for both 24 h and 48 h. As a result of immunohistochemical staining, while both almond oils exhibited significant antiproliferative and anticancer activity, these activities were more similar in Colo-320 cells which were treated with Northern Cyprus almond oil. DISCUSSION AND

conclusionAlmond oil from Northern Cyprus and Turkey may have anticancer and antiproliferative effects on colon cancer cells through molecular signalling pathways and, thus, they could be potential novel therapeutic agents.

Indexed as

Prunus dulcisSeedsAntineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalColonic NeoplasmsDose-Response Relationship, DrugFatty AcidsHumansPlant Oilsalmond oilAntineoplastic Agents, PhytogenicFatty AcidsPlant OilsAlmond oilcolo-320 cell linecolo-741 cell lineoleic acid

Identifiers

PMID28262033
PMCPMC6130748
OpenAlexW2592917840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.