Evidence map›Paper›PMID 28261707›Full record

ArticleChemical communications (Cambridge, England)2017

Real-time monitoring of conformational transitions of single-molecule histone deacetylase 8 with nanocircuits.

Seungyong You, James Froberg, Junru Yu, Manas Haldar, Abbas Sedigh, Sanku Mallik, D K Srivastava, Yongki Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seungyong YouDepartment of Physics, North Dakota State University, Fargo, North Dakota 58108, USA. yongki.choi@ndsu.edu.
James FrobergDepartment of Physics, North Dakota State University, Fargo, North Dakota 58108, USA. yongki.choi@ndsu.edu.
Junru YuDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, USA.
Manas HaldarDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108, USA.
Abbas SedighDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, USA.
Sanku MallikDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108, USA.
D K SrivastavaDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, USA.
Yongki ChoiDepartment of Physics, North Dakota State University, Fargo, North Dakota 58108, USA. yongki.choi@ndsu.edu.ORCID http://orcid.org/0000-0001-8890-8344

Funding

Pilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9M
Echogenic Polymersomes for Triggered Contents ReleaseR01GM114080 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI MALLIK, SANKU, SARKAR, KAUSIK · 2015 to 2023
$2.6M
Developing a hybrid biomolecule nano-circuit approach for observing and manipulating single protein dynamicsR15GM122063 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI CHOI, YONGKI · 2016 to 2016
$424k
NIGMS NIH HHS P30 GM103332NIGMS NIH HHS R01 GM114080NIGMS NIH HHS R15 GM122063
6 · The paper itself

Abstract

Using single-molecule approaches, we directly observed the dynamic interaction between HDAC8 and various ligands as well as conformational interconversions during the catalytic reaction. Statistical analysis identified key kinetic parameters, demonstrating that the enzymatic activity is highly sensitive to both minor variations in the ligand structures and small synthetic molecules.

Indexed as

Electric ConductivityEquipment DesignHistone Deacetylase InhibitorsHistone DeacetylasesHumansHydroxamic AcidsKineticsLigandsNanotechnologyNanotubes, CarbonProtein ConformationRepressor ProteinsVorinostatHDAC8 protein, humanHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic AcidsLigandsNanotubes, CarbonRepressor ProteinsVorinostat

Identifiers

PMID28261707
PMCPMC5510773

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.