Evidence map›Paper›PMID 28261667›Full record

ArticlemSphere

Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs.

Anastasia N Vlasova, Francine C Paim, Sukumar Kandasamy, Moyasar A Alhamo, David D Fischer, Stephanie N Langel, Loic Deblais, Anand Kumar, Juliet Chepngeno, Lulu Shao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effects of Defined Pig Microbiota on Acute Salmonellosis in Gnotobiotic Piglets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. [Establishment of a nomogram model for predicting necrotizing enterocolitis in very preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Article
  14. Article
  15. Vaccines · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Anastasia N VlasovaFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.ORCID 0000-0002-1447-6283
Francine C PaimFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Sukumar KandasamyFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Moyasar A AlhamoFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
David D FischerFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Stephanie N LangelFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Loic DeblaisFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Anand KumarFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Juliet ChepngenoFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Lulu ShaoFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Huang-Chi HuangFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Rosario A Candelero-RuedaFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Gireesh RajashekaraFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
Linda J SaifFood Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, Ohio, USA.
The Ohio State University · US

Funding

Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccinesR01AI099451 · NIAID · OHIO STATE UNIVERSITY · PI RAJASHEKARA, GIREESH, SAIF, LINDA J. · 2012 to 2016
$2.2M
NIAID NIH HHS R01 AI099451
6 · The paper itself

Abstract

Malnutrition affects millions of children in developing countries, compromising immunity and contributing to increased rates of death from infectious diseases. Rotavirus is a major etiological agent of childhood diarrhea in developing countries, where malnutrition is prevalent. However, the interactions between the two and their combined effects on immune and intestinal functions are poorly understood. In this study, we used neonatal gnotobiotic (Gn) pigs transplanted with the fecal microbiota of a healthy 2-month-old infant (HIFM) and fed protein-deficient or -sufficient bovine milk diets. Protein deficiency induced hypoproteinemia, hypoalbuminemia, hypoglycemia, stunting, and generalized edema in Gn pigs, as observed in protein-malnourished children. Irrespective of the diet, human rotavirus (HRV) infection early, at HIFM posttransplantation day 3 (PTD3), resulted in adverse health effects and higher mortality rates (45 to 75%) than later HRV infection (PTD10). Protein malnutrition exacerbated HRV infection and affected the morphology and function of the small intestinal epithelial barrier. In pigs infected with HRV at PTD10, there was a uniform decrease in the function and/or frequencies of natural killer cells, plasmacytoid dendritic cells, and CD103

Indexed as

gnotobiotic pigletshuman infant fecal microbiotahuman rotavirusinnate immunityintestinal epithelial barrierintestinal epithelial cellsnatural killer cellsplasmacytoid dendritic cellsprotein deficiency

Identifiers

PMID28261667
PMCPMC5332602
OpenAlexW2592604110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.