Evidence map›Paper›PMID 28261594›Full record

ArticleHepatobiliary surgery and nutrition2017

Hepatocellular carcinoma with macrovascular invasion treated with yttrium-90 radioembolization prior to transplantation.

Giovanni Battista Levi Sandri, Giuseppe Maria Ettorre, Marco Colasanti, Edoardo De Werra, Gianluca Mascianà, Daniele Ferraro, Giovanni Tortorelli, Rosa Sciuto, Pierleone Lucatelli, Giuseppe Pizzi and 2 more

Abstract read
In one paragraph

Article in Hepatobiliary surgery and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Observational
  5. Yttrium-90 Radioembolization: Current Indications and Outcomes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Review
  6. Article
  7. Neoadjuvant treatment strategies for hepatocellular carcinoma.World journal of gastrointestinal surgery · 2021
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Treatment strategies for locally advanced hepatocellular carcinoma.Translational gastroenterology and hepatology · 2019
    Review
  19. Article
  20. Liver transplant for patients outside Milan criteria.Translational gastroenterology and hepatology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Giovanni Battista Levi SandriDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Giuseppe Maria EttorreDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Marco ColasantiDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Edoardo De WerraDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Gianluca MascianàDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Daniele FerraroDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Giovanni TortorelliDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.
Rosa SciutoDivision of Nuclear Medicine, IFO Regina Elena National Cancer Institute, Rome, Italy.
Pierleone LucatelliDivision of Interventional Radiology, IFO Regina Elena National Cancer Institute, Rome, Italy.
Giuseppe PizziDivision of Interventional Radiology, IFO Regina Elena National Cancer Institute, Rome, Italy.
Ubaldo Visco-ComandiniDivision of Hepatology and Infectious Disease, National Institute for Infectious Disease "L. Spallanzani", Rome, Italy.
Giovanni VennarecciDivision of General Surgery and Liver Transplantation, San Camillo Hospital Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYttrium-90 microspheres radioembolization (Y90-RE) has shown to be an effective and safe treatment of primary liver tumors. According to the staging system of the Barcelona Clinic Liver Cancer (BCLC), patients with macrovascular invasion are staged as BCLC-C. This paper comprises a presentation of the results following application of the procedure.

methodsFrom January 2002 to December 2015, 367 patients were transplanted at the San Camillo Hospital Center. One hundred and forty-three patients were transplanted for hepatocellular carcinoma (HCC) and in 22 cases patients were treated with Y90-RE before liver transplantation (LT), of them 4 with macrovascular invasion were included in this study.

resultsThe four patients had a complete response for the thrombosis, and were included in the waiting list within the Milan criteria. Means interval time between Y90-RE and LT was 15.86 months. No patient death was observed at Y90-RE procedure or at LT. We obtain a free-survival of 39.1 (range, 6-76) months. In all four cases the complete thrombosis regression was observed.

conclusionsWe reported a short series of patients transplanted after Y90-RE in patients with BCLC stage C. In our experience we achieved acceptable overall and disease-free survival. Eventually, Y90-RE seems to have a place in the downstaging strategy for LT candidates.

Indexed as

Barcelona Clinic Liver Cancer (BCLC)downstaginghepatocellular carcinoma (HCC)liver transplantation (LT)macrovascular invasionradioembolizationYttrium

Identifiers

PMID28261594
PMCPMC5332219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.