ReviewHepatobiliary surgery and nutrition2017
Pathology of intrahepatic cholangiocarcinoma.
Review in Hepatobiliary surgery and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 123 citations in OpenAlex.
- Down-regulation of lncRNA-NEF indicates poor prognosis in intrahepatic cholangiocarcinoma.Bioscience reports · 2019Trial
- Prognostic Implications of CT- and MRI-Based LI-RADS Category M Features in Intrahepatic Cholangiocarcinoma: An Intraindividual Comparison.Korean journal of radiology · 2026Article
- Counterfactual Diffusion Models Provide Interpretable Explanations of Artificial Intelligence Models in Pathology.Cancer research · 2026Article
- HCC within LR-M on CEUS LI-RADS: preliminary analysis of washout timing & intensity.Abdominal radiology (New York) · 2026Article
- A Dual-Gene Signature of PMAIP1 and GADD45A for Early Detection of Intrahepatic Cholangiocarcinoma in the Context of Primary Sclerosing Cholangitis.International journal of molecular sciences · 2026Article
- Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target.Nature communications · 2026Article
- Surgical management of intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma: a narrative review of principles, technical nuances, and emerging strategies.Journal of liver cancer · 2026Review
- Efficacy of transarterial chemoembolization combined with PD-1 versus PD-L1 inhibitors in mass-forming intrahepatic cholangiocarcinoma: a multicenter retrospective study.Translational cancer research · 2026Article
- Recent advances in molecular classification and multimodal treatment of intrahepatic cholangiocarcinoma.World journal of surgical oncology · 2026Review
- A LODDS and PNI-based personalized prognostic model for patients with gastric cancer receiving neoadjuvant chemotherapy.Frontiers in nutrition · 2026Article
- A personalized prognostic model based on preoperative body composition and nutritional parameters for gastric cancer patients receiving neoadjuvant chemotherapy.Frontiers in immunology · 2026Article
- Advancements in intratumoral therapies for liver tumors.Frontiers in oncology · 2026Review
- Case Report: Diffuse peribiliary metastasis from ovarian cancer mimicking sclerosing cholangitis without a detectable mass.Frontiers in oncology · 2026Article
- The post-surgical liver: is application of treatment response assessment within the CEUS LI-RADS framework possible?Abdominal radiology (New York) · 2025Article
- Artificial intelligence in the diagnosis and prognosis of intrahepatic cholangiocarcinoma: Applications and challenges.World journal of gastrointestinal oncology · 2025Review
- Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior.Diagnostic pathology · 2025Article
- Counterfactual Diffusion Models for Interpretable Morphology-based Explanations of Artificial Intelligence Models in Pathology.bioRxiv : the preprint server for biology · 2025Article
- Association between ultrasound-based biliary and parenchymal intrahepatic mass-forming cholangiocarcinoma subtypes and clinicopathological features and survival.Insights into imaging · 2025Article
- An explainable machine learning model for predicting the risk of distant metastasis in intrahepatic cholangiocarcinoma: a population-based cohort study.Discover oncology · 2025Article
- Classification of intrahepatic cholangiocarcinoma.Abdominal radiology (New York) · 2025Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrahepatic cholangiocarcinoma (iCC) is a primary carcinoma of the liver with increasing significance and major pathogenic, clinical and therapeutic challenges. Classically, it arises from malignant transformation of cholangiocytes bordering small portal bile duct (BD) to second-order segmental large BDs. It has three major macroscopic growth pattern [mass-forming (MF), periductal infiltrative (PI), and intraductal growth (IG)] and histologically is a desmoplastic stroma-rich adenocarcinoma with cholangiocyte differentiation. Recent data pointed out noteworthy degree of heterogeneity in regards of their epidemiology and risk factors, pathological and molecular features, pathogenesis, clinical behaviors and treatment. Notably, several histological variants are described and can coexist within the same tumor. Several different cells of origin have also been depicted in a fraction of iCCs, amongst which malignant transformation of ductules, of hepatic stem/progenitor cells, of periductal glands or through oncogenic reprogramming of adult hepatocytes. A degree of pathological overlap with hepatocellular carcinoma (HCC) may be observed in a portion of iCC. A series of precursor lesions are today characterized and emphasize the existence of a multistep carcinogenesis process. Overall, these new data have brought up in proposal of new histological or molecular classifications, which could soon replace current anatomic-based classification and could have major impact on establishment of prognosis and on development of novel target treatment approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.