ReviewFrontiers in pediatrics2017
Understanding the Full Spectrum of Organ Injury Following Intrapartum Asphyxia.
Review in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Pooled it
- Neonatal PBPK model of midazolam and its metabolites for perinatal asphyxia and therapeutic hypothermia.British journal of clinical pharmacology · 2026Article
- Neonatal Acute Kidney Injury-An Australian and New Zealand Perspective.Journal of paediatrics and child health · 2026Review
- Preserved Acute Pulmonary Endothelial Homeostasis with Hydrogen Gas Inhalation After Neonatal Hypoxia-Ischemia Despite Increased Neutrophil Accumulation.Biomedicines · 2026Article
- Predicting the Outcome of Sick Neonates Using the Sick Neonate Score: A Prospective Observational Study.Cureus · 2026Article
- Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model.Scientific reports · 2026Article
- Persistence of right ventricular dysfunction in infants after perinatal asphyxia treated with therapeutic hypothermia.Pediatric research · 2025Article
- Machine learning based clinical decision tool to predict acute kidney injury and survival in therapeutic hypothermia treated neonates.Scientific reports · 2025Article
- Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model.Scientific reports · 2025Article
- Development of the EPO-Score - a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia - a retrospective study.Frontiers in pediatrics · 2025Article
- Echocardiographic evaluation of myocardial dysfunction in term neonates with perinatal asphyxia.Pakistan journal of medical sciences · 2024Article
- Umbilical Cord pH Levels and Neonatal Morbidity and Mortality.JAMA network open · 2024Article
- Feasibility Analysis of ECG-Based pH Estimation for Asphyxia Detection in Neonates.Sensors (Basel, Switzerland) · 2024Article
- Echocardiographic and ultrasound evaluation of haemodynamic parameters in hypoxic neonates treated with hypothermia: Study protocol.Frontiers in pediatrics · 2023Article
- Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease: a nationwide population-based study of term infants.The Lancet regional health. Europe · 2023Article
- Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps.Frontiers in pediatrics · 2023Review
- Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets.Frontiers in pediatrics · 2023Article
- Pathophysiology of Perinatal Asphyxia in Humans and Animal Models.Biomedicines · 2022Review
- Dogs as a Natural Animal Model of Epilepsy.Frontiers in veterinary science · 2022Review
- Hemodynamic response to milrinone for refractory hypoxemia during therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Birth asphyxia is a significant global health problem, responsible for ~1.2 million neonatal deaths each year worldwide. Those who survive often suffer from a range of health issues including brain damage-manifesting as cerebral palsy (CP)-respiratory insufficiency, cardiovascular collapse, and renal dysfunction, to name a few. Although the majority of research is directed toward reducing the brain injury that results from intrapartum birth asphyxia, the multi-organ injury observed in surviving neonates is of equal importance. Despite the advent of hypothermia therapy for the treatment of hypoxic-ischemic encephalopathy (HIE), treatment options following asphyxia at birth remain limited, particularly in low-resource settings where the incidence of birth asphyxia is highest. Furthermore, although cooling of the neonate results in improved neurological outcomes for a small proportion of treated infants, it does not provide any benefit to the other organ systems affected by asphyxia at birth. The aim of this review is to summarize the current knowledge of the multi-organ effects of intrapartum asphyxia, with particular reference to the findings from our laboratory using the precocial spiny mouse to model birth asphyxia. Furthermore, we reviewed the current treatments available for neonates who have undergone intrapartum asphyxia, and highlight the emergence of maternal dietary creatine supplementation as a preventative therapy, which has been shown to provide multi-organ protection from birth asphyxia-induced injury in our preclinical studies. This cheap and effective nutritional supplement may be the key to reducing birth asphyxia-induced death and disability, particularly in low-resource settings where current treatments are unavailable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.