Evidence map›Paper›PMID 28261332›Full record

ArticleJournal of Cancer2017

Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years.

Veronika Weyerer, Roland Schneckenpointner, Thomas Filbeck, Maximilian Burger, Ferdinand Hofstaedter, Peter J Wild, Samson W Fine, Peter A Humphrey, Louis P Dehner, Mahul B Amin and 10 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  12. Ki-67 Expression as a Predictive Factor of Muscle Invasion in Bladder Cancer.Open access Macedonian journal of medical sciences · 2018
    Article
  13. Journal of Cancer · 2018
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 7 countries.

Veronika WeyererInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Roland SchneckenpointnerDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Thomas FilbeckDepartment of Urology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Maximilian BurgerSt Josef Medical Center, Department of Urology, University of Regensburg, Regensburg, Germany.
Ferdinand HofstaedterTumor Center Regensburg, University of Regensburg, Regensburg, Germany.
Peter J WildDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich 8091, Switzerland.
Samson W FineDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peter A HumphreyDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Louis P DehnerDivision of Anatomic and Molecular Pathology, Department of Pathology and Immunology, St. Louis Children's Hospital, Washington University Medical Center, St. Louis, MO, USA.
Mahul B AminDepartment of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Josef RüschoffPathology Nordhessen, Kassel, Germany.
Carsten BoltzeInstitute of Pathology, SRH-Klinikum, Gera, Germany.
Andrea TannapfelInstitute for Pathology, Ruhr-University, Bochum, Germany.
Ellen ZwarthoffDepartment of Pathology, Erasmus Medical Centre, Rotterdam, the Netherlands.
Antonio Lopez-BeltranDepartment of Surgery, Cordoba University Medical School, Cordoba, Spain.
Rodolfo MontironiSection of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Cord LangnerInstitute of Pathology, Medical University of Graz, Graz, Austria.
Robert StoehrInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Arndt HartmannInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Johannes GiedlInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Universitätsklinikum Erlangen · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Regensburg · DECedars-Sinai Medical Center · USErasmus University Rotterdam · NLMarche Polytechnic University · ITMedical University of Graz · ATMemorial Sloan Kettering Cancer Center · USRuhr University Bochum · DESRH Wald-Klinikum Gera · DEUniversity Hospital of Zurich · CHUniversity of Córdoba · ESWashington University Medical Center · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. Only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. We collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to test genomic alterations typically found in bladder cancer. Tumours of 118 early-onset patients were compared with a consecutive group of 113 cases. Immunohistochemistry of TP53, CK20 and Ki-67 was carried out. Molecular analysis was conducted to test for loss of heterozygosity of chromosome 9 and 17, as well as

Indexed as

Bladder cancerEarly-onsetFGFR3Mutation analysis.TP53 positivity

Identifiers

PMID28261332
PMCPMC5332882
OpenAlexW2589678904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.