Evidence map›Paper›PMID 28261202›Full record

ArticleFrontiers in immunology2017

Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis.

Ying Xiong, Lisbeth Berrueta, Katia Urso, Sara Olenich, Igla Muskaj, Gary J Badger, Antonios Aliprantis, Robert Lafyatis, Helene M Langevin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ying XiongDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Lisbeth BerruetaDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Katia UrsoDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Sara OlenichDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Igla MuskajDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Gary J BadgerDepartment of Medical Biostatistics, University of Vermont , Burlington, VT , USA.
Antonios AliprantisDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
Robert LafyatisUniversity of Pittsburgh, School of Medicine , Pittsburgh, PA , USA.
Helene M LangevinDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurological Sciences, University of Vermont, Burlington, VT, USA.
Brigham and Women's Hospital · USHarvard University · USUniversity of Pittsburgh · USUniversity of Vermont · USUniversity of Vermont Medical Center · US

Funding

Effect of Stretching on Inflammatory ResolutionR01AT009267 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI LANGEVIN, HELENE M · 2016 to 2018
$1.4M
6 · The paper itself

Abstract

objectiveAlthough physical therapy can help preserve mobility in patients with systemic sclerosis (SSc), stretching has not been used systematically as a treatment to prevent or reverse the disease process. We previously showed in rodent models that stretching promotes the resolution of connective tissue inflammation and reduces new collagen formation after injury. Here, we tested the hypothesis that stretching would impact scleroderma development using a mouse sclerodermatous graft-versus-host disease (sclGvHD) model.

methodsThe model consists in the adoptive transfer (allogeneic) of splenocytes from B10.D2 mice (graft) into Rag2

resultsWeekly ultrasound measurements of skin thickness and subcutaneous tissue mobility in the back (relative tissue displacement during passive trunk motion) successfully captured the different phases of the sclGvHD model. Stretching reduced skin thickness and increased subcutaneous tissue mobility compared to no stretching at week 3. Stretching also reduced the expression of CCL2 and ADAM8 in the skin at week 4, which are two genes known to be upregulated in both murine sclGvHD and the inflammatory subset of human SSc. However, there was no evidence that stretching attenuated inflammation at week 2.

conclusionDaily stretching for 10 min can improve skin thickness and mobility in the absence of any other treatment in the sclGvHD murine model. These pre-clinical results suggest that a systematic investigation of stretching as a therapeutic modality is warranted in patients with SSc.

Indexed as

fibrosisGvHDinflammationphysical therapysclerodermastretchingsystemic sclerosis

Identifiers

PMID28261202
PMCPMC5311037
OpenAlexW2589031892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.