ReviewFrontiers in neuroscience2017
The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.
Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Effects of circadian rhythm on anaerobic performance and blood lactate level: a systematic review.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Effects of physical activity on sleep problems in breast cancer survivors: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men.Physiological reports · 2021Trial
- Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm.Bone research · 2026Review
- Association of accelerometer-derived sleep characteristics with incident osteoporosis: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- Comparison of post-activation performance enhancement in the lower limbs of short sprinters based on two velocity loss thresholds.Frontiers in sports and active living · 2026Article
- Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Association between different modes of physical activity and sleep disorders in young and middle-aged adults: a population-based study.European journal of medical research · 2025Article
- Peripheral clocks and systemicFrontiers in endocrinology · 2025Review
- Exercise, circadian rhythms, and muscle regeneration: a path to healthy aging.Frontiers in neuroscience · 2025Review
- Physical inactivity and breakfast skipping caused visceral fat accumulation in rats.Scientific reports · 2024Article
- The specificities, influencing factors, and medical implications of bone circadian rhythms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Circadian Regulation of Bone Remodeling.International journal of molecular sciences · 2024Review
- Effect of changes in sleeping behavior on skeletal muscle and fat mass: a retrospective cohort study.BMC public health · 2023Article
- Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Circadian Clock and Nutrition.Nutrients · 2023Article
- Effects of chronotype on antidepressant treatment and symptoms in patients with depression: a multicenter, parallel, controlled study.BMC psychiatry · 2023Article
- Optimal velocity loss threshold for inducing post activation potentiation in track and field athletes.Biology of sport · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.