ArticleInternational journal of nanomedicine2017
Preparation of a nano- and micro-fibrous decellularized scaffold seeded with autologous mesenchymal stem cells for inguinal hernia repair.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Advances in Innovative Surgical Implant Manufacturing for Hernia Repair and Soft Tissue Reconstruction.Bioengineering (Basel, Switzerland) · 2025Review
- The Importance of Sex-Based Comparisons in Preclinical Nanomedicine and Regenerative Chronic Wound Therapies.ACS biomaterials science & engineering · 2025Review
- The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review.Biomedical engineering online · 2023Review
- A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment.International journal of nanomedicine · 2018Article
- Invited comment to: Minimal modulation of the host immune response to small intestinal submucosa by mesenchymal stem cells from the amniotic fluid. F. Lesagne, S. Pranpanus, F.M. Bosisio, M. Jacobs, S. Ospitalieri, J. Toelen, J. Deprest.Hernia : the journal of hernias and abdominal wall surgery · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosthetic meshes used for hernioplasty are usually complicated with chronic pain due to avascular fibrotic scar or mesh shrinkage. In this study, we developed a tissue-engineered mesh (TEM) by seeding autologous bone marrow-derived mesenchymal stem cells onto nanosized fibers decellularized aorta (DA). DA was achieved by decellularizing the aorta sample sequentially with physical, mechanical, biological enzymatic digestion, and chemical detergent processes. The tertiary structure of DA was constituted with micro-, submicro-, and nanosized fibers, and the original strength of fresh aorta was retained. Inguinal hernia rabbit models were treated with TEMs or acellular meshes (AMs). After implantation, TEM-treated rabbit models showed no hernia recurrence, whereas AM-treated animals displayed bulges in inguinal area. At harvest, TEMs were thicker, have less adhesion, and have stronger mechanical strength compared to AMs (
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Registered trials
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