Evidence map›Paper›PMID 28260863›Full record

Trial reportDrug design, development and therapy2017

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the

Choon Ok Kim, Eun Sil Oh, Hohyun Kim, Min Soo Park

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Choon Ok KimDepartment of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul.
Eun Sil OhDepartment of Pharmaceutical Medicine and Regulatory Sciences, College of Medicine and Pharmacy, Yonsei University, Incheon.
Hohyun KimKorea Medicine Research Institute, Inc., Seongnam.
Min Soo ParkDepartment of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Yonsei University · KRKorea Medicine Research Institute · KRSeverance Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK) interactions between these two drugs in healthy males and to explore the effect of

Indexed as

AdultCross-Over StudiesCytochrome P-450 CYP2C9Drug InteractionsHealthy VolunteersHumansLiver-Specific Organic Anion Transporter 1MaleMiddle AgedPharmacogenomic TestingPolymorphism, GeneticRosuvastatin CalciumSulfonylurea CompoundsYoung AdultCYP2C9 protein, humanCytochrome P-450 CYP2C9glimepirideLiver-Specific Organic Anion Transporter 1Rosuvastatin CalciumSLCO1B1 protein, humanSulfonylurea CompoundsCYP2C9glimepiridepharmacokineticsrosuvastatinSLCO1B1

Identifiers

PMID28260863
PMCPMC5330189
OpenAlexW2591471945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.