Evidence map›Paper›PMID 28260855›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2017

Profound vision loss impairs psychological well-being in young and middle-aged individuals.

Giancarlo A Garcia, Matin Khoshnevis, Jesse Gale, Starleen E Frousiakis, Tiffany J Hwang, Lissa Poincenot, Rustum Karanjia, David Baron, Alfredo A Sadun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Quality of life with anophthalmia: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  2. Capturing the experiences of patients with inherited optic neuropathies: a systematic review of patient-reported outcome measures (PROMs) and qualitative studies.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Pooled it
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  6. Risk of mental health disorders following traumatic ocular and orbital injury.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Giancarlo A GarciaDoheny Eye Institute, Los Angeles, CA, USA; University of California, Irvine School of Medicine, Irvine, CA, USA.
Matin KhoshnevisDoheny Eye Institute, Los Angeles, CA, USA; Department of Ophthalmology, Temple University, Philadelphia, PA, USA.
Jesse GaleDoheny Eye Institute, Los Angeles, CA, USA; Wellington School of Medicine and Health Sciences, University of Otago, Wellington, NZ.
Starleen E FrousiakisDoheny Eye Institute, Los Angeles, CA, USA; Department of Ophthalmology, New York Medical College, Valhalla, NY, USA.
Tiffany J HwangDoheny Eye Institute, Los Angeles, CA, USA; Department of Psychiatry & The Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lissa PoincenotDoheny Eye Institute, Los Angeles, CA, USA.
Rustum KaranjiaDoheny Eye Institute, Los Angeles, CA, USA; Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles California, CA, USA; Department of Ophthalmology, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Health Research Institute, Ottawa, ON, Canada.
David BaronDepartment of Psychiatry & The Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alfredo A SadunDoheny Eye Institute, Los Angeles, CA, USA; Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles California, CA, USA.
Doheny Eye Institute · USOttawa Hospital · CAUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the effects of profound vision loss on psychological well-being in adolescents, young adults, and middle-aged adults with regard to mood, interpersonal interactions, and career-related goals. In addition, we assessed the significance of the resources that may be used to enhance psychological well-being in cases of profound vision loss, and in particular, examined the utility of low vision aids and the role of the ophthalmologist as a provider of emotional support.

methodsA questionnaire was issued to individuals aged 13-65 years with profound vision loss resulting from Leber's hereditary optic neuropathy (LHON). Depression prevalence was evaluated with questions regarding major depressive disorder symptomatology. Participants appraised the effects of vision loss on their interpersonal interactions and career goals by providing an impact rating (IR) on a 21-point psychometric scale from -10 to +10. Social well-being index was defined as the average of interpersonal IR and career IR. Subjects were additionally asked about the use of low vision aids and sources of emotional support.

resultsA total of 103 participants (mean age =26.4±11.2 years at LHON diagnosis; mean ± standard deviation) completed the questionnaire. Nearly half (49.5%) met the depression criteria after vision loss. Negative impacts on interpersonal interactions (median IR = -5) and career goals (median IR = -6) were observed; both ratings were worse (

conclusionProfound vision loss in adolescents, young adults, and middle-aged adults is associated with significant negative psychological and psychosocial effects, which are influenced by age and use of electronic vision aids. Ophthalmologists, in addition to managing vision loss, may serve an important role in the emotional adaptation of these patients.

Indexed as

depressionLeber’s hereditary optic neuropathylow vision aidspsychologicalquality of lifevision loss

Identifiers

PMID28260855
PMCPMC5328297
OpenAlexW2590364048

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.