ArticleJournal of computational physics2016
A 4DCT imaging-based breathing lung model with relative hysteresis.
Article in Journal of computational physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- Multiscale simulation of respiratory airflow using physiologically consistent geometry and boundary conditions in OpenFOAM.Computers in biology and medicine · 2025Article
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Modeling Realistic Geometries in Human Intrathoracic Airways.Diagnostics (Basel, Switzerland) · 2024Review
- Functional analysis of the airways after pulmonary lobectomy through computational fluid dynamics.Scientific reports · 2022Article
- Computational fluid dynamics of the airways after left-upper pulmonary lobectomy: A case study.International journal for numerical methods in biomedical engineering · 2021Article
- The effect of airway motion and breathing phase during imaging on CFD simulations of respiratory airflow.Computers in biology and medicine · 2020Article
- AVATREE: An open-source computational modelling framework modelling Anatomically Valid Airway TREE conformations.PloS one · 2020Article
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Localization of adventitious respiratory sounds.The Journal of the Acoustical Society of America · 2018Article
- Contributions of Kinetic Energy and Viscous Dissipation to Airway Resistance in Pulmonary Inspiratory and Expiratory Airflows in Successive Symmetric Airway Models With Various Bifurcation Angles.Journal of biomechanical engineering · 2018Article
- A multiscale analytical model of bronchial airway acoustics.The Journal of the Acoustical Society of America · 2017Article
- A four-dimensional computed tomography comparison of healthy and asthmatic human lungs.Journal of biomechanics · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To reproduce realistic airway motion and airflow, the authors developed a deforming lung computational fluid dynamics (CFD) model based on four-dimensional (4D, space and time) dynamic computed tomography (CT) images. A total of 13 time points within controlled tidal volume respiration were used to account for realistic and irregular lung motion in human volunteers. Because of the irregular motion of 4DCT-based airways, we identified an optimal interpolation method for airway surface deformation during respiration, and implemented a computational solid mechanics-based moving mesh algorithm to produce smooth deforming airway mesh. In addition, we developed physiologically realistic airflow boundary conditions for both models based on multiple images and a single image. Furthermore, we examined simplified models based on one or two dynamic or static images. By comparing these simplified models with the model based on 13 dynamic images, we investigated the effects of relative hysteresis of lung structure with respect to lung volume, lung deformation, and imaging methods, i.e., dynamic vs. static scans, on CFD-predicted pressure drop. The effect of imaging method on pressure drop was 24 percentage points due to the differences in airflow distribution and airway geometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.