ArticleThe Journal of veterinary medical science2017
Analysis of DNA methylation of potential age-related methylation sites in canine peripheral blood leukocytes.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Less-invasive age estimation using hair based on DNA methylation in brown bears.Scientific reports · 2025Article
- Epigenetic Clock in Bears: A Simple Cost-Effective Blood DNA Methylation-Based Age Estimation Method Applicable to Multiple Bear Species.Ecology and evolution · 2025Article
- Methodology Advances in Vertebrate Age Estimation.Animals : an open access journal from MDPI · 2024Review
- Hibernation slows epigenetic ageing in yellow-bellied marmots.Nature ecology & evolution · 2022Article
- An epigenetic clock to estimate the age of living beluga whales.Evolutionary applications · 2021Article
- Efficacy of Sox10 Promoter Methylation in the Diagnosis of Intestinal Neuronal Dysplasia From the Peripheral Blood.Clinical and translational gastroenterology · 2019Article
- Article
- Estimation of chimpanzee age based on DNA methylation.Scientific reports · 2018Article
- Measuring Animal Age with DNA Methylation: From Humans to Wild Animals.Frontiers in genetics · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable methodology for predicting the age of mature dogs is currently unavailable. In this study, amplicon sequencing of 50 blood samples obtained from diseased dogs was used to measure methylation in seven DNA regions. Significant correlations between methylation level and age were identified in four of the seven regions. These four regions were then tested in samples from 31 healthy toy poodles, and correlations were detected in two regions. The age of another 11 dogs was predicted using data from the diseased dogs and the healthy poodles. The mean difference between the actual and calculated ages was 34.3 and 23.1 months, respectively. Further research is needed to identify additional sites of age-related methylation and allow accurate age prediction in dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.