ReviewJournal of atherosclerosis and thrombosis2017
Evidence-Based Carotid Interventions for Stroke Prevention: State-of-the-art Review.
Review in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segments.The Cochrane database of systematic reviews · 2022Pooled it
- Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event.Journal of atherosclerosis and thrombosis · 2018Trial
- Carotid Artery Stenting Outcomes by Neurointerventional Surgeons (CASONI).Stroke (Hoboken, N.J.) · 2025Article
- Seizures Following Carotid Endarterectomy: A Comprehensive Meta-Analysis of 69,479 Patients and Evidence-Based Recommendations for Perioperative Care.Diagnostics (Basel, Switzerland) · 2024Article
- Investigating the Added Value of Beck's Depression Inventory in Atherosclerosis Prediction: Lessons from Paracelsus 10,000.Journal of clinical medicine · 2024Article
- Risk factors of in-stent restenosis after carotid angioplasty and stenting: long-term follow-up study.Frontiers in neurology · 2024Article
- Article
- Multiple hypointense veins on susceptibility weighted imaging as a promising biomarker of impaired cerebral hemodynamics in chronic steno-occlusive disease: a multiparametric MRI study.Neuroradiology · 2022Article
- Carotid Endarterectomy.Advances and technical standards in neurosurgery · 2022Article
- Functional MRI evaluation of the effect of carotid artery stenting: a case study demonstrating cognitive improvement.Acta radiologica open · 2021Article
- Long-term imaging follow-up to evaluate restenosis in patients with carotid stenosis after angioplasty and stenting.Journal of the Chinese Medical Association : JCMA · 2021Article
- Aortic Valve Sclerosis as an Important Predictor of Long-Term Mortality in Patients With Carotid Atheromatous Plaque Requiring Carotid Endarterectomy.Frontiers in cardiovascular medicine · 2021Article
- Personalized-medicine on carotid endarterectomy and stenting.Annals of translational medicine · 2020Review
- Auscultation System for Acquisition of Vascular Sounds - Towards Sound-Based Monitoring of the Carotid Artery.Medical devices (Auckland, N.Z.) · 2020Article
- Geometric determinants of local hemodynamics in severe carotid artery stenosis.Computers in biology and medicine · 2019Article
- Comparison of Long Term Prognosis between Carotid Endarterectomy versus Stenting; A Korean Population-Based Study Using National Insurance Data.Neurointervention · 2019Article
- Noninvasive Assessment of Stenotic Severity and Plaque Characteristics by Coronary CT Angiography in Patients Scheduled for Carotid Artery Revascularization.Journal of atherosclerosis and thrombosis · 2018Article
- Asymptomatic Carotid Stenosis: Intervention or Best Medical Therapy?Current neurology and neuroscience reports · 2018Review
- LINC01088 Targets miR-195-5p to Promote Proliferation and Migration and Reduce Apoptosis in the Inhibition of Carotid Artery Stenosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
- Role ofWorld journal of nuclear medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotid artery stenosis is responsible for between 10-20% of all ischaemic strokes. Interventions, such as carotid endarterectomy and carotid stenting, effectively reduce the risk of stroke in selected individuals. This review describes the history of carotid interventions, and summarises reliable evidence on the safety and efficacy of these interventions gained from large randomised clinical trials.Early trials comparing carotid endarterectomy to medical therapy alone in symptomatic patients, and asymptomatic patients, demonstrated that endarterectomy halved the risk of stroke and perioperative death in these two unique populations. The absolute risk reduction was smaller in the asymptomatic carotid trials, consistent with their lower absolute stroke risk. More recent trials in symptomatic patients, suggest that carotid stenting has similar long term durability to carotid endarterectomy, but possibly has higher procedural hazards dominated by non-disabling strokes. The Asymptomatic Carotid Surgery Trial-2, along with individual patient data meta-analysis of all asymptomatic trials, will provide reliable evidence for the choice of intervention in asymptomatic patients in whom a decision has been made for carotid revascularisation. Given improvements in effective cardiovascular medical therapy, in particular lipid-lowering medications, there is renewed uncertainty as to whether carotid interventions still provide meaningful net reductions in stroke risk in asymptomatic populations. Four large trials in Europe and the US are currently underway, and are expected to report long-term results in the next decade.It is essential that surgeons, interventionalists, and physicians continue to randomise large numbers of patients from around the world to clarify current uncertainty around the management of asymptomatic carotid stenosis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.