Evidence map›Paper›PMID 28260693›Full record

ArticleAging2017

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.

Sana Siddiqui, Ana Lustig, Arnell Carter, Mathavi Sankar, Caitlin M Daimon, Richard T Premont, Harmonie Etienne, Jaana van Gastel, Abdelkrim Azmi, Jonathan Janssens and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection.Journal of the American Society of Nephrology : JASN · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Transcription-Related Dynamics from Immune Disability into Endogenous Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
  12. G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence.Computational and structural biotechnology journal · 2019
    Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Sana SiddiquiReceptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD 21224, USA.
Ana LustigLaboratory of Molecular Biology and Immunology, NIA, NIH, Baltimore, MD 21224, USA.
Arnell CarterLaboratory of Molecular Biology and Immunology, NIA, NIH, Baltimore, MD 21224, USA.
Mathavi SankarMetabolism Unit, Laboratory of Clinical Investigation, NIA, NIH, Baltimore, MD 21224, USA.
Caitlin M DaimonMetabolism Unit, Laboratory of Clinical Investigation, NIA, NIH, Baltimore, MD 21224, USA.
Richard T PremontDuke University Medical Center, Durham, NC 27705, USA.
Harmonie EtienneTranslational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp, Belgium.
Jaana van GastelTranslational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp, Belgium.
Abdelkrim AzmiTranslational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp, Belgium.
Jonathan JanssensTranslational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp, Belgium.
Kevin G BeckerGene Expression and Genomics Unit, Research Resources Branch, NIA, NIH, Baltimore, MD 21224, USA.
Yongqing ZhangGene Expression and Genomics Unit, Research Resources Branch, NIA, NIH, Baltimore, MD 21224, USA.
William WoodGene Expression and Genomics Unit, Research Resources Branch, NIA, NIH, Baltimore, MD 21224, USA.
Elin LehrmannGene Expression and Genomics Unit, Research Resources Branch, NIA, NIH, Baltimore, MD 21224, USA.
James G MartinResearch Institute of the MUHC, Centre for Translational Biology (CTB), Meakins-Christie Laboratories, McGill University, Montreal, QC, H4A 3J1, Canada.
Bronwen MartinMetabolism Unit, Laboratory of Clinical Investigation, NIA, NIH, Baltimore, MD 21224, USA.
Dennis D TaubLaboratory of Molecular Biology and Immunology, NIA, NIH, Baltimore, MD 21224, USA.
Stuart MaudsleyReceptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD 21224, USA.
National Institute on Drug Abuse · USUniversity of Antwerp · BEVIB-UAntwerp Center for Molecular Neurology · BEDuke University Hospital · USMcGill University · CANational Institute on Aging · USNational Institutes of Health · US

Funding

Analysis of complex biological systems by microarray based gene expressionZICAG000616 · NIA · NATIONAL INSTITUTE ON AGING · PI DE, SUPRIYO · 2009 to 2025
$15.5M
6 · The paper itself

Abstract

Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks of the aging process is thymic involution. At a relatively young age, 12 months old, GIT2

Indexed as

AgingAging, PrematureAnimalsCell Cycle ProteinsCellular SenescenceGTPase-Activating ProteinsImmune SystemIntercellular Signaling Peptides and ProteinsKeratin-8MiceMice, Inbred C57BLMice, KnockoutPhosphoproteinsSignal TransductionThymus GlandTranscriptomeCell Cycle ProteinsGit2 protein, mouseGTPase-Activating ProteinsIntercellular Signaling Peptides and ProteinsKeratin-8Krt8 protein, mousePhosphoproteinsagingbioinformaticsclockCXCR4GIT2metabolismT cell differentiationthymic involution

Identifiers

PMID28260693
PMCPMC5391227
OpenAlexW2593936227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.