Trial reportInternational urology and nephrology2017
The role of pregabalin in relieving ureteral stent-related symptoms: a randomized controlled clinical trial.
Trial report in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- The Beneficial Effects of Alpha-Blockers, Antimuscarinics, Beta 3-Agonist, and PDE5-Inhibitors for Ureteral Stent-Related Discomfort: A Systematic Review and Meta-Analysis from KSER Update Series.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Combination of solifenacin and tamsulosin may provide additional beneficial effects for ureteral stent-related symptoms-outcomes from a network meta-analysis.World journal of urology · 2019Pooled it
- The role of solifenacin, as monotherapy or combination with tamsulosin in ureteral stent-related symptoms: a systematic review and meta-analysis.World journal of urology · 2017Pooled it
- The effects of pregabalin, solifenacin and their combination therapy on ureteral double-J stent-related symptoms: A randomized controlled clinical trial.International braz j urol : official journal of the Brazilian Society of UrologyTrial
- Postoperative pain management after ureteroscopy: focused approaches to reducing opiate dependence.Pain management · 2025Review
- A critical review on the role of perioperative pregabalin in ureteroscopy for urolithiasis.Translational andrology and urology · 2024Article
- Comparing efficacy and safety of mirabegron, tamsulosin, and solifenacin in ureteral stent-related symptoms: outcomes from a network meta-analysis.Translational andrology and urology · 2024Article
- Is dismissing preoperative pregabalin premature?-the role of gabapentinoids in multimodal pain management following ureteroscopic stone surgery.Translational andrology and urology · 2024Article
- Pharmacological treatment of bladder stent symptoms.Bladder (San Francisco, Calif.) · 2024Review
- Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents.Research and reports in urology · 2020Review
- Relation of postoperative pain medication to return for unplanned care after ureteroscopy.Proceedings (Baylor University. Medical Center) · 2019Article
- Ureteral Stent Discomfort and Its Management.Current urology reports · 2018Review
- Combined gabapentin and solifenacin for symptom management after double-J stent insertion: Randomized controlled trial.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the role of pregabalin in relieving USRS in patients with an indwelling double-J (DJ) stents. PATIENTS AND
methodsA total of 500 adult patients with a unilateral single ureteral stone who underwent ureteroscopic stone management and required DJ stent insertion were prospectively included in our study. Patients were blindly assigned into four groups A, B, C and D. Those in group A were managed with combination of solifenacin 5-mg tablets and pregabalin 75-mg capsules bid. Patients in group B were managed with solifenacin 5-mg tablets. Those in group C were managed with pregabalin 75-mg capsules bid. Those in group D were control group. All patients were evaluated on day 15 postoperatively for stent-related symptoms using the Arabic translated and validated ureteral stent symptom questionnaire (USSQ).
resultsThe total USSQ score as well as general health index was significantly lower in group A as compared to other groups. In addition, urinary symptom index was significantly improved in both groups A and B as compared to group C and group D. Pain symptom index was significantly improved in both groups A and C as compared to groups B and D. No statistically significant difference was reported regarding sexual index and work performance index among the whole study groups.
conclusionPregabalin appears to be a well-tolerated, safe and effective drug in reducing most of USRS, especially relief of pain with subsequent improvement of patient's quality of life. Its combination with solifenacin should be considered to manage patients with USRS as it shows a significant improvement in total USSQ score and general health index when compared to each drug alone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.