Evidence map›Paper›PMID 28260177›Full record

ArticleCancer causes & control : CCC2017

Older age at the completion of linear growth is associated with an increased risk of adult glioma.

Rebecca B Little, L Burt Nabors, Jeffrey J Olson, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Peter A Forsyth, Reid C Thompson, Robert A Oster, Sajeel A Chowdhary and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Immune Subtypes and Survival in Patients with Primary Glioma.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Handedness and the risk of glioma.Journal of neuro-oncology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rebecca B LittleDepartment of Nutrition Sciences, University of Alabama at Birmingham, Webb 449, 1675 University Blvd., Birmingham, AL, 35294, USA.
L Burt NaborsNeuro-oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
Jeffrey J OlsonDepartment of Neurosurgery, Emory University School of Medicine, 1365-B Clifton Rd., NE, Ste. 2200, Atlanta, GA, 30322, USA.
Zachary J ThompsonDivision of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Carrie M RozmeskiDivision of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Renato V LaRoccaDepartment of Hematology-Oncology, Norton Cancer Institute, 676 So Floyd St., Louisville, KY, 40202, USA.
Peter A ForsythDepartment of Neuro-oncology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Reid C ThompsonDepartment of Neurological Surgery, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN, 37232, USA.
Robert A OsterDepartment of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, MT 642, 1717 11th Ave. South, Birmingham, AL, 35205, USA.
Sajeel A ChowdharyNeuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, FL, 33486, USA.
Kathleen M EganDivision of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. Kathleen.egan@moffitt.org.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Southeast Region Case-Control Study of Adult GliomaR01CA116174 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI EGAN, KATHLEEN M. · 2007 to 2011
$4.9M
Training Program in Brain Tumor BiologyT32NS048039 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2007 to 2017
$2.0M
NCATS NIH HHS UL1 TR001417NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA116174NINDS NIH HHS T32 NS048039
6 · The paper itself

Abstract

purposeTo examine the association of age when adult height was attained with glioma risk.

methodsWe analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height.

resultsThe study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height.

conclusionsWe observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.

Indexed as

Adolescent DevelopmentBody HeightAdolescentAdultAgedAged, 80 and overBrain NeoplasmsCase-Control StudiesFemaleGliomaHumansLogistic ModelsMaleMiddle AgedOdds RatioRisk FactorsAdolescenceCase–control studiesGlioblastomaGliomaHeightMenarche

Identifiers

PMID28260177
PMCPMC5469709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.