Evidence map›Paper›PMID 28260123›Full record

SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2017

The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer.

Anastasia Prodromidou, Panagiotis Andreakos, Charalampos Kazakos, Dimitrios Eftimios Vlachos, Despina Perrea, Vasilios Pergialiotis

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. The Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Deep Venous Thrombosis: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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  9. Gender differences in systemic inflammatory and nutritional index following radical surgery for advanced gastric cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anastasia ProdromidouLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece. a.prodromidou@hotmail.com.
Panagiotis AndreakosLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece.
Charalampos KazakosLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece.
Dimitrios Eftimios VlachosLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece.
Despina PerreaLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece.
Vasilios PergialiotisLaboratory of Experimental Surgery and Surgical Research N.S.Christeas, Medical School, National and Kapodistrian University of Athens, 15B Agiou Thoma str Goudi, 115 23, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatelet-to-lymphocyte (PLR) and Neutrophil-to-Lymphocyte (NLR) ratios have been extensively investigated in cancer. However, to date, actual guidelines concerning ovarian cancer are missing. The purpose of the present systematic review is to summarize the available evidence.

methodsWe systematically searched Medline (1966-2016), Scopus (2004-2016), ClinicalTrials.gov (2008-2016), and Cochrane Central Register of Controlled Trials CENTRAL (1999-2016) databases together with reference lists from included studies.

resultsEighteen studies were included in the present systematic review that involved 3453 patients. According to the current data, both PLR and NLR values in ovarian cancer patients seem to deviate from healthy controls. Furthermore, they may also be indicative of the stage of the disease and of the response to chemotherapy. Nevertheless, their diagnostic accuracy remains limited as their sensitivity and specificity are moderate (detects 55-80% of ovarian cancer women).

conclusionAccording to the findings of our study, both PLR and NLR seem to be promising screening and prognostic factors of epithelial ovarian cancer. The actual diagnostic cut-off values remain, however, undefined until now. Despite their limited sensitivity and specificity, they might be useful in the future as adjunct biomarkers for the detection and surveillance of the disease.

Indexed as

Blood PlateletsLymphocytesNeutrophilsFemaleHumansLeukocyte CountOvarian NeoplasmsPlatelet CountNLROSOvarian cancerPFSPLR

Identifiers

PMID28260123
OpenAlexW2592970620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.