Evidence map›Paper›PMID 28260057›Full record

ArticleMolecular medicine reports2017

Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis.

Xiaoliang Zhou, Yanli Wang, Yuzhong Wang, Peter Cipriano, Bo Xiao, Wenbin Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiaoliang ZhouDepartment of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
Yanli WangDepartment of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei 434020, P.R. China.
Yuzhong WangDepartment of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
Peter CiprianoDepartment of Radiology, Stanford Medical Center, Stanford, CA 94305, USA.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
Wenbin ZhouDepartment of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China.
Central South University · CNAffiliated Hospital of Jining Medical University · CNStanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17) peptide is a competitive antagonist of TREM‑1. To investigate the role of TREM‑1 in EAN, 64 male Lewis rats were randomly divided into four groups: Normal saline, complete Freund's adjuvant, EAN and LP 17. The present study assessed the mRNA expression levels of TREM‑1, tumor necrosis factor‑α and interleukin‑1β in sciatic nerves and peripheral blood mononuclear cells. The results demonstrated that inhibiting TREM-1 by administering LP 17 ameliorated symptoms and reduced inflammation in EAN rats. The present study concluded that TREM‑1 may be involved in the pathogenesis of EAN, and that inhibition of TREM-1 may ameliorate EAN.

Indexed as

AnimalsGene Expression RegulationInterleukin-1betaMaleNeuritis, Autoimmune, ExperimentalRats, Inbred LewReceptors, ImmunologicRNA, MessengerSciatic NerveStaining and LabelingTriggering Receptor Expressed on Myeloid Cells-1Tumor Necrosis Factor-alphaInterleukin-1betaReceptors, ImmunologicRNA, MessengerTREM1 protein, ratTriggering Receptor Expressed on Myeloid Cells-1Tumor Necrosis Factor-alpha

Identifiers

PMID28260057
PMCPMC5365016
OpenAlexW2586424467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.