ArticleMolecular medicine reports2017
Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Diagnostic Value and Molecular Function of MicroRNAs in Endometrial Diseases: A Systematic Review.Cancers · 2024Review
- When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation.International journal of molecular sciences · 2024Review
- Bioinformatic analysis of endometrial miRNA expression profile at day 26-28 of pregnancy in the mare.Scientific reports · 2024Article
- MicroRNAs in the Regulation of Endometrial Receptivity for Embryo Implantation.International journal of molecular sciences · 2022Review
- Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review.Journal of clinical medicine · 2021Review
- miR-21a inhibits decidual cell apoptosis by targeting Pdcd4.Genes & diseases · 2021Article
- Epigenetic modifications working in the decidualization and endometrial receptivity.Cellular and molecular life sciences : CMLS · 2020Review
- Identification of Immune Response to Sacbrood Virus Infection inFrontiers in genetics · 2020Article
- MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson's disease.Molecular medicine (Cambridge, Mass.) · 2018Article
- Next-generation sequencing-based microRNA profiling of mice testis subjected to transient heat stress.Oncotarget · 2017Article
- Role of microRNAs in embryo implantation.Reproductive biology and endocrinology : RB&E · 2017Review
- Profile of MicroRNA Expression in Endometrial Cell duringTissue engineering and regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decidualization of endometrial stromal cells is an important feature of implantation and pregnancy. The molecular mechanism underlying decidualization remains unclear, particularly regarding the microRNA (miRNA/miR) regulation of this process. The present study revealed the temporal and spatial distribution of mmu‑miR‑96 in the mouse uterus during early pregnancy by reverse transcription‑quantitative polymerase chain reaction and in situ hybridization. In addition, primary stromal cells were isolated from the mouse uterus and used to explore the role of mmu‑miR‑96 in decidualization. The results demonstrated that mmu‑miR‑96 was highly expressed in stromal cells during pregnancy, and was upregulated at implantation sites. In addition, mmu‑miR‑96 was strongly expressed during decidualization, which indicates that it may serve a role in the decidualization of stromal cells. Based on existing reports, mmu‑miR‑96 participates in apoptosis; therefore the present study investigated its effects on the apoptosis of primary endometrial stromal cells. The results indicated that overexpression of mmu‑miR‑96 may induce apoptosis of stromal cells. In further studies regarding the underlying mechanism, the target genes of mmu‑miR‑96 were screened by bioinformatics analysis, and it was confirmed that B‑cell lymphoma 2, an anti‑apoptotic gene, was the target of mmu‑miR‑96, as determined using a reporter gene assay. In conclusion, the present study suggested that mmu‑miR‑96 participates in the decidualization of endometrial stromal cells in mice, thereby serving a key role in pregnancy.
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