Evidence map›Paper›PMID 28259546›Full record

ReviewProstaglandins & other lipid mediators2017

Who is the real 12-HETrE?

Jennifer Yeung, Michael Holinstat

Open access · greenAbstract readReview
In one paragraph

Review in Prostaglandins & other lipid mediators, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer YeungDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, United States.
Michael HolinstatDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, United States. Electronic address: mholinst@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitusR01HL114405 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2013 to 2017
$1.9M
12-HETrE regulation of plateletsR01GM105671 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2013 to 2017
$1.6M
12-lipoxygenase regulation of FcgRIIa-mediated platelet activationF31HL129481 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YEUNG, JENNIFER · 2015 to 2017
$106k
NHLBI NIH HHS F31 HL129481NHLBI NIH HHS R01 HL114405NIGMS NIH HHS R01 GM105671
6 · The paper itself

Abstract

Oxygenases, including lipoxygenases and cytochrome P450s, generate an array of structurally diverse oxylipins that modulate distinct biological responses in mammals. Depending on the source of tissues and enzymes, distinct oxylipins are generated with inherent cellular function. Here, we report structurally different forms of 12-HETrE, with distinct biological function in tissues as well as their derived enzymatic source.

Indexed as

8,11,14-Eicosatrienoic AcidAnimalsBlood PlateletsCytochrome P-450 Enzyme SystemHumansLipoxygenases12-hydroxy-8,10,14-eicosatrienoic acid8,11,14-Eicosatrienoic AcidCytochrome P-450 Enzyme SystemLipoxygenases12(R)-HETrE12(S)-HETrEArachidonic acidDihomo-gamma-linolenic acidPlatelet 12-LOXThrombosis

Identifiers

PMID28259546
PMCPMC5581286
OpenAlexW2592878577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.