ArticleParasites & vectors2017
Molecular and serological evidence of flea-associated typhus group and spotted fever group rickettsial infections in Madagascar.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Potential zoonotic rickettsiales bacteria associated with small mammals and their ectoparasites in africa: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review.The American journal of tropical medicine and hygiene · 2020Pooled it
- The flea Xenopsylla brasiliensis in Madagascar: updated distribution, host interactions, and initial assessment of insecticide susceptibility.Scientific reports · 2026Article
- Bioecology of fleas with a focus on the plague vector Xenopsylla Brasiliensis in Mandritsara district, Northern Madagascar.Scientific reports · 2025Article
- Predictive multi-omic biomarkers for urban zoonotic spillover detection: an integrative review.Frontiers in public health · 2025Review
- Molecular detection and characterization ofInfection ecology & epidemiology · 2025Article
- Socio-ecological risk factors associated with human flea infestations of rural household in plague-endemic areas of Madagascar.PLoS neglected tropical diseases · 2024Article
- Fecal elimination of fluralaner in different carnivore species after oral administration.Frontiers in veterinary science · 2024Article
- Molecular Evidence for Flea-Borne Rickettsiosis in Febrile Patients from Madagascar.Pathogens (Basel, Switzerland) · 2021Article
- International Rickettsia Disease Surveillance: An Example of Cooperative Research to Increase Laboratory Capability and Capacity for Risk Assessment of Rickettsial Outbreaks Worldwide.Frontiers in medicine · 2021Review
- Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island.BMC research notes · 2019Article
- Seroprevalence and Risk Factors forThe American journal of tropical medicine and hygiene · 2019Article
- Molecular detection of Rickettsia felis in dogs, rodents and cat fleas in Zambia.Parasites & vectors · 2019Article
- Study on causes of fever in primary healthcare center uncovers pathogens of public health concern in Madagascar.PLoS neglected tropical diseases · 2018Article
- Tick-, Flea-, and Louse-Borne Diseases of Public Health and Veterinary Significance in Nigeria.Tropical medicine and infectious disease · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundRickettsiae are obligate intracellular bacteria responsible for many febrile syndromes around the world, including in sub-Saharan Africa. Vectors of these pathogens include ticks, lice, mites and fleas. In order to assess exposure to flea-associated Rickettsia species in Madagascar, human and small mammal samples from an urban and a rural area, and their associated fleas were tested.
resultsAnti-typhus group (TGR)- and anti-spotted fever group rickettsiae (SFGR)-specific IgG were detected in 24 (39%) and 21 (34%) of 62 human serum samples, respectively, using indirect ELISAs, with six individuals seropositive for both. Only two (2%) Rattus rattus out of 86 small mammals presented antibodies against TGR. Out of 117 fleas collected from small mammals, Rickettsia typhi, a TGR, was detected in 26 Xenopsylla cheopis (24%) collected from rodents of an urban area (n = 107), while two of these urban X. cheopis (2%) were positive for Rickettsia felis, a SFGR. R. felis DNA was also detected in eight (31%) out of 26 Pulex irritans fleas.
conclusionsThe general population in Madagascar are exposed to rickettsiae, and two flea-associated Rickettsia pathogens, R. typhi and R. felis, are present near or in homes. Although our results are from a single district, they demonstrate that rickettsiae should be considered as potential agents of undifferentiated fever in Madagascar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.