ArticleMalaria journal2017
In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products.
Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Antiplasmodial Activity and Safety Evaluation of Three Widely Distributed Polyherbal Antimalarials in Ghana.Journal of tropical medicine · 2026Article
- The efficacy of selected Ghanaian herbal antimalarials against laboratory strains and clinical isolates of Plasmodium falciparum.Scientific reports · 2025Article
- Integrating modern and herbal medicines in controlling malaria: experiences of orthodox healthcare providers in Ghana.Archives of public health = Archives belges de sante publique · 2024Article
- Identification of Commercial Antimalarial Herbal Drugs Using Laser-Induced Autofluorescence Technique and Multivariate Algorithms.Journal of fluorescence · 2024Article
- Automatic Classification of Antimalarial Herbal Drugs Exposed to Ultraviolet Radiation from Unexposed Ones Using Laser-Induced Autofluorescence with Chemometric Techniques.Journal of fluorescence · 2024Article
- Article
- Zero malaria: a mirage or reality for populations of sub-Saharan Africa in health transition.Malaria journal · 2022Review
- The practice of integrated healthcare and the experiences of people in Ghana's Ashanti region.BMC health services research · 2022Article
- Formulation and In Vitro Evaluation of Oral Capsules from Liquid Herbal Antimalarials Marketed in Ghana.Journal of tropical medicine · 2021Article
- The Effectiveness of Varying Combination Ratios ofJournal of parasitology research · 2020Article
- Microbial, phytochemical, toxicity analyses and antibacterial activity against multidrug resistant bacteria of some traditional remedies sold in Buea Southwest Cameroon.BMC complementary and alternative medicine · 2019Article
- Integrating herbal medicine into mainstream healthcare in Ghana: clients' acceptability, perceptions and disclosure of use.BMC complementary and alternative medicine · 2017Article
- The application of Signalling Theory to health-related trust problems: The example of herbal clinics in Ghana and Tanzania.Social science & medicine (1982) · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is inadequate or unreliable data on their efficacy and quality. An assessment of the potency and quality of the most popular commercial anti-malarial HPs in Ghana was, therefore, carried out. The outcome of this investigation is herein discussed preceded by a short literature review of herbal medicines in Ghana.
methodsUsing a questionnaire survey of 344 individuals in parts of Ghana, five of the most frequently used HPs were identified and selected for test of their efficacy and quality. The effect of the selected compounds on Plasmodium berghei in vivo was assessed using standard methods.
resultsAll five tested HPs (HP-A, HP-B, HP-C, HP-D and HP-E) showed chemo-suppressive activity against P. berghei in vivo. However the degree of parasites inhibition is significantly lower compared to the WHO-recommended artemether-lumefantrine combination (p < 0.05, 99.9% chemosuppression/activity, 28 days survival). Using the Solomon Saker's Test, two of the preparations were found to contain chloroquine or compounds with chemical properties like that of chloroquine.
conclusionPopular anti-malarial HPs used in southern Ghana were found to have chemo-suppressive properties. Intentional addition of chloroquine or SCs to these preparations in order to enhance their effectiveness has serious public health concerns as it may induce cross resistance to amodiaquine, one of the partner drugs in the recommended ACT for use in Ghana.
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