ArticleNeurobiology of aging2017
Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- An operant-based touchscreen morph discrimination task does not detect age-related mnemonic similarity deficits in rats.Oxford open neuroscience · 2026Article
- Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats.Frontiers in aging neuroscience · 2026Article
- Effects of cannabis smoke and oral Δ9THC on cognition in young adult and aged rats.Psychopharmacology · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Neuropsychology of cognitive aging in rhesus monkeys.Neurobiology of aging · 2023Article
- Article
- Neuropsychology of cognitive aging in rhesus monkeys.bioRxiv : the preprint server for biology · 2023Article
- Potential trade-off between olfactory and visual discrimination learning in common marmosets (Callithrix jacchus): Implications for the assessment of age-related cognitive decline.American journal of primatology · 2022Article
- Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums.Scientific reports · 2021Article
- Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.Neurobiology of aging · 2021Article
- Olfactory Detection Thresholds for Primary Aliphatic Alcohols in Mice.Chemical senses · 2020Article
- The perirhinal cortex supports spatial intertemporal choice stability.Neurobiology of learning and memory · 2019Article
- Impaired discrimination with intact crossmodal association in aged rats: A dissociation of perirhinal cortical-dependent behaviors.Behavioral neuroscience · 2018Article
- Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.Trends in neurosciences · 2018Review
- Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats.Neurobiology of aging · 2017Article
- Rodent age-related impairments in discriminating perceptually similar objects parallel those observed in humans.Hippocampus · 2017Article
- Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination.Frontiers in systems neuroscience · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Emerging evidence suggests that aging is associated with a reduced ability to distinguish perceptually similar stimuli in one's environment. As the ability to accurately perceive and encode sensory information is foundational for explicit memory, understanding the neurobiological underpinnings of discrimination impairments that emerge with advancing age could help elucidate the mechanisms of mnemonic decline. To this end, there is a need for preclinical approaches that robustly and reliably model age-associated perceptual discrimination deficits. Taking advantage of rodents' exceptional olfactory abilities, the present study applied rigorous psychophysical techniques to the evaluation of discrimination learning in young and aged F344 rats. Aging did not influence odor detection thresholds or the ability to discriminate between perceptually distinct odorants. In contrast, aged rats were disproportionately impaired relative to young on problems that required discriminations between perceptually similar olfactory stimuli. Importantly, these disproportionate impairments in discrimination learning did not simply reflect a global learning impairment in aged rats, as they performed other types of difficult discriminations on par with young rats. Among aged rats, discrimination deficits were strongly associated with spatial learning deficits. These findings reveal a new, sensitive behavioral approach for elucidating the neural mechanisms of cognitive decline associated with normal aging.
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