Evidence map›Paper›PMID 28259037›Full record

ArticlePsychiatry research2017

Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.

Marie Hennebelle, Yurika Otoki, Jun Yang, Bruce D Hammock, Anthony J Levitt, Ameer Y Taha, Walter Swardfager

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
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  4. The unique reactivity of EKODE lipid peroxidation products allows in vivo detection of inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Soluble Epoxide Hydrolase and Diabetes Complications.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
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  15. A single meal has the potential to alter brain oxylipin content.Prostaglandins, leukotrienes, and essential fatty acids · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Marie HennebelleDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: mhennebelle@ucdavis.edu.
Yurika OtokiDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA; Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan. Electronic address: yotoki@ucdavis.edu.
Jun YangDepartment of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: junyang@ucdavis.edu.
Bruce D HammockDepartment of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: bdhammock@ucdavis.edu.
Anthony J LevittHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada. Electronic address: anthony.levitt@sunnybrook.ca.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: ataha@ucdavis.edu.
Walter SwardfagerHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON Canada. Electronic address: w.swardfager@utoronto.ca.
University of California, Davis · USSunnybrook Health Science Centre · CASunnybrook Research InstituteTohoku University · JP

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
NIDDK NIH HHS U24 DK097154NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710
6 · The paper itself

Abstract

Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.

Indexed as

Epoxide HydrolasesSeasonsAdultFatty Acids, Omega-3Fatty Acids, Omega-6FemaleGas Chromatography-Mass SpectrometryHumansInflammationLinoleic AcidsMajor Depressive DisorderMaleMiddle AgedOxylipinsSeasonal Affective DisorderTandem Mass Spectrometry13-hydroxy-9,11-octadecadienoic acidEpoxide HydrolasesFatty Acids, Omega-3Fatty Acids, Omega-6Linoleic AcidsOxylipinsCytochrome p450DepressionFatty acidsLipidomicsOmega-3Omega-6OxylipinsSeasonal major depressionSoluble epoxide hydrolase

Identifiers

PMID28259037
PMCPMC5611448
OpenAlexW2592582363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.