Trial reportEBioMedicine2017
Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents.
Trial report in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis.EBioMedicine · 2018Pooled it
- Prediction of the efficacy of group cognitive behavioral therapy using heart rate variability based smart wearable devices: a randomized controlled study.BMC psychiatry · 2024Trial
- Distinct and shared therapeutic neural mechanisms of mindfulness-based and social support stress reduction groups in adults with autism spectrum disorder.Journal of psychiatry & neuroscience : JPNTrial
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Biomarkers associated with treatment outcome in young people with depression: A systematic review.Neuroscience applied · 2024Review
- Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders.Neuroscience applied · 2024Article
- Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.Brain and behavior · 2023Article
- Functional connectomics in depression: insights into therapies.Trends in cognitive sciences · 2023Review
- Evaluation of brain structure and metabolism in currently depressed adults with a history of childhood trauma.Translational psychiatry · 2022Article
- In(s) and out(s) of adolescent depression - Trajectories of development and recovery.Brain, behavior, & immunity - health · 2021Article
- A lateralized model of the pain-depression dyad.Neuroscience and biobehavioral reviews · 2021Review
- Resting State Functional Connectivity Biomarkers of Treatment Response in Mood Disorders: A Review.Frontiers in psychiatry · 2021Review
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients With Mild Brain Injury: A Multiple Case Study.Frontiers in human neuroscience · 2020Article
- Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury.Human brain mapping · 2018Article
- Emotion dysregulation and functional connectivity in children with and without a history of major depressive disorder.Cognitive, affective & behavioral neuroscience · 2018Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional ('hot') and cognitive control ('cold') neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of 'hot' emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of 'cold' cognition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.