ArticleNeuroscience bulletin2017
A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children.
Article in Neuroscience bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Abnormal amygdala functional connectivity and deep learning classification in multifrequency bands in autism spectrum disorder: A multisite functional magnetic resonance imaging study.Human brain mapping · 2023Pooled it
- Alterations in Amygdala and Hippocampal Volumes in Autism Spectrum Disorder: Meta-analysis.Journal of autism and developmental disorders · 2026Article
- Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3BNature communications · 2025Article
- Neurotransmitter Systems Affected by PBDE Exposure: Insights from In Vivo and In Vitro Neurotoxicity Studies.Toxics · 2025Review
- Peripheral oxytocin levels are linked to hypothalamic gray matter volume in autistic adults: a cross-sectional secondary data analysis.Scientific reports · 2024Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Vasopressin as Possible Treatment Option in Autism Spectrum Disorder.Biomedicines · 2023Review
- Oxytocin and arginine vasopressin: a bridge between acupuncture and autism spectrum disorder.Medical review (2021) · 2022Article
- Affective Empathy, Theory of Mind and Social Functioning in Patients With Focal Epilepsy.Frontiers in psychiatry · 2022Article
- Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review.Frontiers in neuroscience · 2022Review
- Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder.Neuroscience bulletin · 2021Review
- The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder.Handbook of clinical neurology · 2021Review
- Understanding Hippocampal Development in Young Children With Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders.Brain sciences · 2020Review
- Perinatal exposure to octabromodiphenyl ether mixture, DE-79, alters the vasopressinergic system in adult rats.Toxicology and applied pharmacology · 2020Article
- Towards the Framework of Understanding Autism Spectrum Disorders.Neuroscience bulletin · 2019Article
- Endothelin neurotransmitter signalling controls zebrafish social behaviour.Scientific reports · 2019Article
- Differences in oxytocin and vasopressin levels in individuals suffering from the autism spectrum disorders vs general population - a systematic review.Neuropsychiatric disease and treatment · 2019Article
- Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.Schizophrenia research · 2018Article
- Structural connectivity of the amygdala in young adults with autism spectrum disorder.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysfunction of brain-derived arginine-vasopressin (AVP) systems may be involved in the etiology of autism spectrum disorder (ASD). Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social behaviors. The present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity (FC) of specific brain regions in autistic children compared with typically developing children (TDC) aged from 3 to 5 years. The results showed: (1) children with ASD had a significantly increased volume in the left amygdala and left hippocampus, and a significantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level. (2) Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist. (3) The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD. (4) Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC. (5) The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating scale. These results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.
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