ArticleSocial psychiatry and psychiatric epidemiology2017
Gender differences in the effects of childhood adversity on alcohol, drug, and polysubstance-related disorders.
Article in Social psychiatry and psychiatric epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Gender Differences in the Association Between Adverse Childhood Experiences and Health Risk Behaviors in the Mountain West.AJPM focus · 2026Article
- Gender Differences in Adverse Childhood Experiences, Psychological Distress, and Substance Use Disorder Among Persons who Inject Drugs in Northeast Georgia, USA: A Moderated Mediation Analysis.Journal of child & adolescent trauma · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Childhood maltreatment and early-onset substance use: sex differences in the impact of various types of maltreatment and psychiatric comorbidity.BMC psychiatry · 2026Article
- Overdose risk profiles in pregnancy: Latent class analysis of pregnant individuals with opioid use disorder.Journal of substance use and addiction treatment · 2025Article
- Gender differences in circumstances associated with cannabis use.The American journal on addictions · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Early life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter.Drug and alcohol dependence · 2025Article
- Adulthood trajectories of resilience and vulnerability: exploring gender differences in disadvantage after experience of out-of-home care.BMC public health · 2025Article
- Family Perspectives on Stigma Toward Women Who Use Drugs in Tanzania.Issues in mental health nursing · 2025Article
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
- Childhood adversity and psychopathology: the dimensions of timing, type and chronicity in a population-based sample of high-risk adolescents.Child and adolescent psychiatry and mental health · 2024Article
- Giving Voice to Women with Substance Use Disorder: Findings from Expressive Writing About Trauma.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events.Journal of mental health & clinical psychology · 2024Article
- Prevalence and predictors of depressive and anxiety symptoms in a sample of women who use drugs in Tanzania: the key role of drug use stigma.BMC psychiatry · 2023Article
- Differential prevalence of Adverse Childhood Experiences (ACEs) by gender and substance used in individuals with cannabis, cocaine, opioid, and tobacco use disorders.The American journal of drug and alcohol abuse · 2023Article
- Women-Reported Barriers and Facilitators of Continued Engagement with Medications for Opioid Use Disorder.International journal of environmental research and public health · 2022Article
- A Scoping Review of Gender, Sex and Sexuality Differences in Polysubstance Use in Adolescents and Adults.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms.Frontiers in behavioral neuroscience · 2022Article
- Adverse childhood experiences among females in substance use treatment and their children: A pilot study.Preventive medicine reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine gender differences in the associations between childhood adversity and different types of substance use disorders and whether gender moderates these relationships.
methodsWe analyzed data from 19,209 women and 13,898 men as provided by Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) to examine whether gender moderates the associations between childhood adversity and DSM-IV defined lifetime occurrence of alcohol, drug, and polysubstance-related disorders. We used multinomial logistic regression, weighted to be representative of the US adult civilian, noninstitutionalized population, and we calculated predicted probabilities by gender, controlling for covariates. To test which specific moderation contrasts were statistically significant, we conducted pair-wise comparisons corrected for multiple comparisons using Bonferroni's method.
resultsFor each type of substance use disorder, risk was increased by more exposure to childhood adversity, and women had a lower risk than men. However, moderation effects revealed that with more experiences of childhood adversity, the gender gap in predicted probability for a disorder narrowed in relation to alcohol, it converged in relation to drugs such that risk among women surpassed that among men, and it widened in relation to polysubstances.
conclusionsKnowledge regarding substance-specific gender differences associated with childhood adversity exposure can inform evidence-based treatments. It may also be useful for shaping other types of gender-sensitive public health initiatives to ameliorate or prevent different types of substance use disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.