Evidence map›Paper›PMID 28258320›Full record

ArticleEuropean child & adolescent psychiatry2017

Further evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.

Hermann Pohlabeln, Stefan Rach, Stefaan De Henauw, Gabriele Eiben, Wencke Gwozdz, Charalampos Hadjigeorgiou, Dénes Molnár, Luis A Moreno, Paola Russo, Toomas Veidebaum and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 11 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 11 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  5. Childhood Physical Health and Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Modifiable Factors.Prevention science : the official journal of the Society for Prevention Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 8 countries.

Hermann PohlabelnLeibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany. pohlabeln@leibniz-bips.de.ORCID http://orcid.org/0000-0002-9575-1119
Stefan RachLeibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany.
Stefaan De HenauwDepartment of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Gabriele EibenSection for Epidemiology and Social Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Wencke GwozdzDepartment of Intercultural Communication and Management, Centre for Corporate Social Responsibility, Copenhagen Business School, Copenhagen, Denmark.
Charalampos HadjigeorgiouResearch and Education Institute of Child Health, Strovolos, Cyprus.
Dénes MolnárDepartment of Paediatrics, Medical Faculty, University of Pécs, Pecs, Hungary.
Luis A MorenoGENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), University of Zaragoza, Saragossa, Spain.
Paola RussoUnit of Epidemiology & Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy.
Toomas VeidebaumNational Institute for Health Development, Tallinn, Estonia.
Iris PigeotLeibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany.
IDEFICS consortium
Leibniz Institute for Prevention Research and Epidemiology - BIPS · DECopenhagen Business School · DKGhent University · BEInstitute of Food Science · ITNational Institute for Health Development · EEUniversidad de Zaragoza · ESUniversity of Gothenburg · SEUniversity of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate whether in addition to established early risk factors other, less studied pre-, peri-, and postnatal influences, like gestational hypertension or neonatal respiratory disorders and infections, may increase a child's risk of developing attention-deficit/hyperactivity disorders (ADHD). In the IDEFICS study more than 18,000 children, aged 2-11.9 years, underwent extensive medical examinations supplemented by parental questionnaires on pregnancy and early childhood. The present analyses are restricted to children whose parents also completed a supplementary medical questionnaire (n = 15,577), including the question whether or not the child was ever diagnosed with ADHD. Multilevel multivariable logistic regression was used to assess the association between early life influences and the risk of ADHD. Our study confirms the well-known association between maternal smoking during pregnancy and a child's risk of ADHD. In addition, our study showed that children born to mothers younger than 20 years old were 3-4 times more likely to develop ADHD as compared to children born to mothers aged 25 years and older. Moreover, we found that children whose mothers suffered from pregnancy-induced hypertension had an approximately twofold risk of ADHD (OR 1.95; 95% CI 1.09-3.48). This also holds true for infections during the first 4 weeks after birth (OR 2.06; 95% CI 1.05-4.04). In addition, although not statistically significant, we observed a noticeable elevated risk estimate for neonatal respiratory disorders (OR 1.76; 95% CI 0.91-3.41). Hence, we recommend that these less often studied pre-, peri, and postnatal influences should get more attention when considering early indicators or predictors for ADHD in children. However, special study designs such as genetically sensitive designs may be needed to derive causal conclusions.

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityChildChild, PreschoolCohort StudiesFemaleHumansHypertension, Pregnancy-InducedMalePregnancyPrenatal Exposure Delayed EffectsRisk FactorsTreatment OutcomeYoung AdultAttention-deficit/hyperactivity disordersEuropean children cohortGestational hypertensionMaternal ageNeonatal respiratory disordersSmoking

Identifiers

PMID28258320
OpenAlexW2594595272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.