Evidence map›Paper›PMID 28258220›Full record

ArticleThe Journal of biological chemistry2017

Adiponectin confers protection from acute colitis and restricts a B cell immune response.

Stephanie Obeid, Miriam Wankell, Berenice Charrez, Jade Sternberg, Roxane Kreuter, Saeed Esmaili, Mehdi Ramezani-Moghadam, Carol Devine, Scott Read, Prithi Bhathal and 5 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Adipokines: masterminds of metabolic inflammation.Nature reviews. Immunology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Stephanie ObeidFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Miriam Wankellthe Department of Molecular and Cell Biology and.
Berenice Charrezthe Department of Molecular and Cell Biology and.
Jade Sternbergthe Department of Molecular and Cell Biology and.
Roxane Kreuterthe Department of Molecular and Cell Biology and.
Saeed EsmailiFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Mehdi Ramezani-MoghadamFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Carol DevineFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Scott ReadFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Prithi Bhathalthe University of Melbourne, Victoria, VIC 3010, Australia, and.
Andreas Lopatathe Department of Molecular and Cell Biology and.
Golo AhlensteilFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Liang QiaoFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Jacob GeorgeFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia.
Lionel HebbardFrom the Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia, lionel.hebbard@jcu.edu.au.
James Cook University · AUWestmead Institute for Medical Research · AUThe University of Sydney · AUAustralian Institute of Tropical Health and Medicine · AUThe University of Melbourne · AUWestmead Hospital · AUWestmead Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin demonstrates beneficial effects in various metabolic diseases, including diabetes, and in bowel cancer. Recent data also suggest a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be elucidated. Adiponectin knock-out mice were orally administered dextran sulfate sodium for 7 days and were compared with wild-type mice. The severity of disease was analyzed histopathologically and through cytokine profiling. HCT116 colonic epithelial cells were employed to analyze the

Indexed as

Acute DiseaseAdiponectinAnimalsApoptosisB-LymphocytesCell ProliferationColitisCytokinesDextran SulfateDisease Models, AnimalHCT116 CellsHomeostasisHumansImmune SystemInflammationIntestinal MucosaAdiponectinadiponectin receptor 1, mouseADIPOQ protein, humanAdipoq protein, mouseADIPOR1 protein, humanCytokinesDextran SulfateReceptors, AdiponectinSTAT3 protein, humanStat3 protein, mouseSTAT3 Transcription FactorTumor Necrosis Factor-alphaadiponectinautoimmunitycolitisobesitySTAT3

Identifiers

PMID28258220
PMCPMC5399108
OpenAlexW2593923162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.