Evidence map›Paper›PMID 28258218›Full record

ArticleThe Journal of biological chemistry2017

Structural analyses of

Tatiana Y Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Aidong Qi, William J Hoekstra, Robert J Schotzinger, John D York, F Peter Guengerich, Galina I Lepesheva

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Deciphering the multidrug resistance paradigm inAntimicrobial agents and chemotherapy · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Bioactive Constituents ofDrug design, development and therapy · 2026
    Review
  20. Design, Synthesis, and Biological Evaluation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatiana Y HargroveFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Laura FriggeriFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Zdzislaw Wawrzakthe Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439.
Aidong QiFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
William J HoekstraViamet Pharmaceuticals, Durham, North Carolina 27703, and.
Robert J SchotzingerViamet Pharmaceuticals, Durham, North Carolina 27703, and.
John D YorkFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
F Peter GuengerichFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Galina I LepeshevaFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, galina.i.lepesheva@vanderbilt.edu.

Funding

Structural Requirements for Sterol 14alpha-DemethylasesR01GM067871 · NIGMS · VANDERBILT UNIVERSITY · PI LEPESHEVA, GALINA I · 2004 to 2023
$7.2M
NIGMS NIH HHS R01 GM067871
6 · The paper itself

Abstract

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such as

Indexed as

AnimalsAntifungal AgentsAzolesCandida albicansCrystallizationFungal ProteinsHemeHumansKineticsLigandsMicrobial Sensitivity TestsProtein BindingProtein ConformationProtonsRatsSterol 14-DemethylaseAntifungal AgentsAzolesFungal ProteinsHemeLigandsProtonsSterol 14-DemethylaseSterolsantifungal drugsCandida albicanscytochrome P450enzyme inhibitorenzyme kineticssterol 14 alpha-demethylase (CYP51)sterol biosynthesisX-ray crystallography

Identifiers

PMID28258218
PMCPMC5399120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.