Evidence map›Paper›PMID 28258189›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Selective expression of TSPAN2 in vascular smooth muscle is independently regulated by TGF-β1/SMAD and myocardin/serum response factor.

Jinjing Zhao, Wen Wu, Wei Zhang, Yao Wei Lu, Emiley Tou, Jiemei Ye, Ping Gao, David Jourd'heuil, Harold A Singer, Mingfu Wu and 1 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  9. Circulation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jinjing ZhaoDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Wen WuDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Wei ZhangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Yao Wei LuDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Emiley TouDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Jiemei YeDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Ping GaoDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
David Jourd'heuilDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Harold A SingerDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Mingfu WuDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Xiaochun LongDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA longx@mail.amc.edu.
Albany Medical Center Hospital · US

Funding

CALCIUM/CALMODULIN ACTIVATED KINIASES IN SMOOTH MUSCLER01HL049426 · NHLBI · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI SINGER, HAROLD A · 1994 to 2019
$6.2M
Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionR01HL121700 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu, YANG Kevin XIANG · 2015 to 2026
$5.4M
Novel Role of MAPK14 in Regulation of VSMC Contractile PhenotypeR01HL122686 · NHLBI · AUGUSTA UNIVERSITY · PI LONG, XIAOCHUN · 2014 to 2022
$4.0M
NHLBI NIH HHS R01 HL049426NHLBI NIH HHS R01 HL121700NHLBI NIH HHS R01 HL122686
6 · The paper itself

Abstract

Tetraspanins (TSPANs) comprise a large family of 4-transmembrane domain proteins. The importance of TSPANs in vascular smooth muscle cells (VSMCs) is unexplored. Given that TGF-β1 and myocardin (MYOCD) are potent activators for VSMC differentiation, we screened for TGF-β1 and MYOCD/serum response factor (SRF)-regulated

Indexed as

Cell DifferentiationGene Expression RegulationHumansMaleMuscle, Smooth, VascularMyocardinMyocytes, Smooth MuscleNerve Tissue ProteinsNuclear ProteinsPromoter Regions, GeneticSerum Response FactorSmad ProteinsTetraspaninsTrans-ActivatorsTranscriptomeTransforming Growth Factor beta1MyocardinNerve Tissue ProteinsNuclear ProteinsSerum Response FactorSmad ProteinsTetraspaninsTrans-ActivatorsTransforming Growth Factor beta1TSPAN2 protein, humanTspan2 protein, mousearteriovenous fistuladifferentiationphenotypic modulationtetraspanins

Identifiers

PMID28258189
PMCPMC5434656
OpenAlexW2592054416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.