Evidence map›Paper›PMID 28258184›Full record

ArticleGenetics2017

Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult

Andrew Kekūpa'a Knutson, Thea Egelhofer, Andreas Rechtsteiner, Susan Strome

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 67 citations in OpenAlex.

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  6. eIF4E assembly intobioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew Kekūpa'a KnutsonDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064.
Thea EgelhoferDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064.
Andreas RechtsteinerDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064.
Susan StromeDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064 sstrome@ucsc.edu.
University of California, Santa Cruz · US

Funding

UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2M
IMMUNOLOGIC STUDY OF GERM GRANULES IN C. ELEGANS EMBRY0SR01GM034059 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1985 to 2020
$8.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Genome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623k
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
Illumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500k
NCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NIGMS NIH HHS R01 GM034059NIGMS NIH HHS R25 GM058903NIH HHS P40 OD010440NIH HHS S10 OD018174
6 · The paper itself

Abstract

The germ cells of multicellular organisms protect their developmental potential through specialized mechanisms. A shared feature of germ cells from worms to humans is the presence of nonmembrane-bound, ribonucleoprotein organelles called germ granules. Depletion of germ granules in

Indexed as

AnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoplasmic GranulesDEAD-box RNA HelicasesGene Expression RegulationGerm CellsInfertilityNerve Tissue ProteinsRibonucleoproteinsRNARNA-Binding ProteinsSpermatogenesisTranscriptomeCaenorhabditis elegans ProteinsDEAD-box RNA HelicasesGLH-1 protein, C elegansNerve Tissue ProteinsPGL-1 protein, C elegansRibonucleoproteinsRNARNA-Binding ProteinsUNC-119 protein, C elegansCaenorhabditis elegansgermlinegerm-soma antagonismGLH-1PGL-1P granules

Identifiers

PMID28258184
PMCPMC5419467
OpenAlexW2594424912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.