The role of APOE on lipid homeostasis and inflammation in normal brains.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.

1. Meta-analysis of associations of genetic polymorphisms with cerebral vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.Acta neurologica Belgica · 2022
   Pooled it
2. Lipids as Early and Minimally Invasive Biomarkers for Alzheimer's Disease.Current neuropharmacology · 2022
   Pooled it
3. The efficacy of statins in the treatment of Alzheimer's disease: a meta-analysis of randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
   Pooled it
4. Brain, behavior, & immunity - health · 2026
   Article
5. Cholesterol at the Center of Alzheimer's Disease: A Unifying Hypothesis on the Pathogenic Mechanism.Molecules (Basel, Switzerland) · 2026
   Review
6. Association between serum lipid-apolipoprotein alterations and soluble syndecan-1 dynamics in sepsis: impact of apolipoprotein E isoforms.Biochemistry and biophysics reports · 2026
   Article
7. Lipidomic and sterolomic profiles of different brain regions in the mouse model of Alzheimer's disease.Neural regeneration research · 2026
   Article
8. Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance.Cell genomics · 2026
   Article
9. Examining APOE ε4 and Longitudinal Vascular Brain Injury: The Strong Heart Study.Neurology open access · 2026
   Article
10. Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation.Progress in retinal and eye research · 2026
    Review
11. Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.Frontiers in aging · 2026
    Article
12. Effect of time-restricted feeding on cognitive dysfunction in Alzheimer's disease and the role of ApoE polymorphism: protocol for a randomised controlled trial.BMJ open · 2025
    Article
13. ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis.Biochemistry · 2025
    Article
14. Impact of APOE on cerebrovascular lipid profile in Alzheimer's disease.Acta neuropathologica · 2025
    Article
15. Missense Variants in Nutrition-Related Genes: A Computational Study.International journal of molecular sciences · 2025
    Article
16. Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review).International journal of molecular medicine · 2025
    Review
17. Clinical Significance of APOE4 Genotyping: Potential for Personalized Therapy and Early Diagnosis of Alzheimer's Disease.Journal of clinical medicine · 2025
    Review
18. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption.Communications medicine · 2025
    Article
19. Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice.Communications medicine · 2025
    Article
20. Plasma Proteome Profiling Reveals Inflammation Markers and Tafamidis Effects in V30M Transthyretin Polyneuropathy.International journal of molecular sciences · 2025
    Article

37 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as