Evidence map›Paper›PMID 28258043›Full record

ArticlePsychiatry research2017

Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression.

Chenglong Yu, Bernhard T Baune, Julio Licinio, Ma-Li Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenglong YuMind and Brain Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia; School of Medicine, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: chenglong.yu@sahmri.com.
Bernhard T BauneDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia.
Julio LicinioMind and Brain Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia; School of Medicine, Flinders University, Bedford Park, SA 5042, Australia.
Ma-Li WongMind and Brain Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia; School of Medicine, Flinders University, Bedford Park, SA 5042, Australia.

Funding

UCLA PHARMACOGENETICS &PHARMACOGENOMICS RESEARCH GROUPU01GM061394 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LICINIO, JULIO · 2000 to 2005
$4.7M
Depression/Metabolic Syndrome in Mexican-American Women.R01DK063240 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WONG, MA-LI · 2002 to 2006
$1.9M
Pharmacogenetics of Antidepressant DrugsK24RR017365 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WONG, MA-LI · 2003 to 2007
$727k
NCRR NIH HHS K24 RR017365NIDDK NIH HHS R01 DK063240NIGMS NIH HHS U01 GM061394
6 · The paper itself

Abstract

Recent advances in DNA technologies have provided unprecedented opportunities for biological and medical research. In contrast to current popular genotyping platforms which identify specific variations, whole-genome sequencing (WGS) allows for the detection of all private mutations within an individual. Major depressive disorder (MDD) is a chronic condition with enormous medical, social and economic impacts. Genetic analysis, by identifying risk variants and thereby increasing our understanding of how MDD arises, could lead to improved prevention and the development of new and more effective treatments. Here we investigated the distributions of whole-genome single nucleotide variants (SNVs) on 12 different genomic regions for 25 human subjects using the symmetrised Kullback-Leibler divergence to measure the similarity between their SNV distributions. We performed cluster analysis for MDD patients and ethnically matched healthy controls. The results showed that Mexican-American controls grouped closer; in contrast depressed Mexican-American participants grouped away from their ethnically matched controls. This implies that whole-genome SNV distribution on the genomic regions may be related to major depression.

Indexed as

Whole Genome SequencingAdultAgedCase-Control StudiesCluster AnalysisFemaleGenomicsHumansMajor Depressive DisorderMaleMexican AmericansMiddle AgedPolymorphism, Single NucleotideWhite PeopleYoung AdultCluster analysisKullback-Leibler divergenceMajor depressive disorderMexican-AmericanWhole-genome sequencing

Identifiers

PMID28258043
PMCPMC5730269

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.