Evidence map›Paper›PMID 28258033›Full record

ReviewCurrent opinion in cell biology2017

RNP transport in cell biology: the long and winding road.

Carolina Eliscovich, Robert H Singer

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Tagged actin mRNA dysregulation in IGF2BP1[Formula: see text] mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. In Vivo Visualization of Mobile mRNA Particles in Plants Using BglG.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carolina EliscovichDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, United States; Current address: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Robert H SingerDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, United States; Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York 10461, United States; Janelia Research Campus of the HHMI, Ashburn, VA, 20147, United States. Electronic address: robert.singer@einstein.yu.edu.

Funding

Special Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI GUPTA, SANJEEV · 1989 to 2018
$22.9M
Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
NIDDK NIH HHS P30 DK041296NINDS NIH HHS R01 NS083085
6 · The paper itself

Abstract

Regulation of gene expression is key determinant to cell structure and function. RNA localization, where specific mRNAs are transported to subcellular regions and then translated, is highly conserved in eukaryotes ranging from yeast to extremely specialized and polarized cells such as neurons. Messenger RNA and associated proteins (mRNP) move from the site of transcription in the nucleus to their final destination in the cytoplasm both passively through diffusion and actively via directed transport. Dysfunction of RNA localization, transport and translation machinery can lead to pathology. Single-molecule live-cell imaging techniques have revealed unique features of this journey with unprecedented resolution. In this review, we highlight key recent findings that have been made using these approaches and possible implications for spatial control of gene function.

Indexed as

Active Transport, Cell NucleusGene Expression RegulationAnimalsCell NucleusCytoplasmHumansRibonucleoproteinsRNA, MessengerRNA Transportmessenger ribonucleoproteinRibonucleoproteinsRNA, Messenger

Identifiers

PMID28258033
PMCPMC5482755

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.