Evidence map›Paper›PMID 28257976›Full record

ArticleMolecular immunology2017

The PBX1 lupus susceptibility gene regulates CD44 expression.

Yuxin Niu, Mayami Sengupta, Anton A Titov, Seung-Chul Choi, Laurence Morel

Abstract read
In one paragraph

Article in Molecular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Comprehensive summary: the role of PBX1 in development and cancers.Frontiers in cell and developmental biology · 2024
    Review
  4. Article
  5. PBX1: a TALE of two seasons-key roles during development and in cancer.Frontiers in cell and developmental biology · 2024
    Review
  6. Molecular Mechanisms of Lupus Susceptibility Allele PBX1D.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Article
  7. Article
  8. How "Neuronal" Are Human Skin Mast Cells?International journal of molecular sciences · 2022
    Review
  9. Review
  10. PBX1: a key character of the hallmarks of cancer.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuxin NiuDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Mayami SenguptaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Anton A TitovDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Seung-Chul ChoiDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA.
Laurence MorelDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610-0275, USA. Electronic address: morel@ufl.edu.
University of Florida · US

Funding

Characterization of SLE-susceptibility loci on mouse chromosome 1R01AI045050 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Laurence Morel · 2000 to 2026
$11.5M
NIAID NIH HHS R01 AI045050
6 · The paper itself

Abstract

PBX1-d is novel splice isoform of pre-B-cell leukemia homeobox 1 (PBX1) that lacks its DNA-binding and Hox-binding domains, and functions as a dominant negative. We have shown that PBX1-d expression in CD4

Indexed as

Blotting, WesternCD4-Positive T-LymphocytesChromatin ImmunoprecipitationDNA-Binding ProteinsFlow CytometryGene Expression RegulationGenetic Predisposition to DiseaseHumansHyaluronan ReceptorsImmunoprecipitationJurkat CellsLupus Erythematosus, SystemicLymphocyte ActivationMutagenesis, Site-DirectedPre-B-Cell Leukemia Transcription Factor 1Protein IsoformsCD44 protein, humanDNA-Binding ProteinsHyaluronan ReceptorsPBX1 protein, humanPre-B-Cell Leukemia Transcription Factor 1Protein IsoformsProto-Oncogene ProteinsCD44LupusPBX1T cells

Identifiers

PMID28257976
PMCPMC5389453
OpenAlexW2594261775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.