Evidence map›Paper›PMID 28257811›Full record

ArticleCellular signalling2017

Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum.

Sean Singh, Wasima Mohamed, Annelie Aguessy, Ella Dyett, Shriraj Shah, Mohammedasad Khan, Ramamurthy Baskar, Derrick Brazill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Eat Prey, Live:Frontiers in immunology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sean SinghDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA.
Wasima MohamedDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
Annelie AguessyDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA.
Ella DyettDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA.
Shriraj ShahDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA.
Mohammedasad KhanDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA.
Ramamurthy BaskarDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology-Madras, Chennai 600036, India.
Derrick BrazillDepartment of Biological Sciences, Hunter College and The Graduate Center, The City University of New York, New York, NY, USA. Electronic address: brazill@genectr.hunter.cuny.edu.
The Graduate Center, CUNY · USIndian Institute of Technology Madras · IN

Funding

RISE Program Hunter College Option IIIR25GM060665 · NIGMS · HUNTER COLLEGE · PI ORTIZ, BENJAMIN D.,, SERRANO, PETER A · 2000 to 2022
$22.8M
Basic and Translational Research Center for Reducing Health DisparitiesG12MD007599 · NIMHD · HUNTER COLLEGE · PI ANGULO, JESUS A · 2012 to 2017
$14.6M
NIGMS NIH HHS R25 GM060665NIMHD NIH HHS G12 MD007599
6 · The paper itself

Abstract

Multicellular development in Dictyostelium discoideum involves tightly regulated signaling events controlling the entry into development, initiation of aggregation and chemotaxis, and cellular differentiation. Here we show that PkcA, a Dictyostelium discoideum Protein Kinase C-orthologue, is involved in quorum sensing and the initiation of development, as well as cAMP sensing during chemotaxis. Additionally, by epistasis analysis we provide evidence that PkcA and PldB (a Phospholipase D-orthologue) functionally interact to regulate aggregation, differentiation, and cell-cell adhesion during development. Finally, we show that PkcA acts as a positive regulator of intracellular PLD-activity during development. Taken together, our results suggest that PkcA act through PldB, by regulating PLD-activity, in order to control events during development.

Indexed as

ButanolsCell AdhesionCell Adhesion MoleculesCell DifferentiationCell PolarityChemotaxisCyclic AMPDictyosteliumPhosphatidic AcidsPhospholipase DProtein Kinase C-alphaProtozoan ProteinsQuorum SensingSignal TransductionButanolsCell Adhesion Moleculescell cohesion molecule, DictyosteliumCyclic AMPPhosphatidic AcidsPhospholipase Dphospholipase D1Protein Kinase C-alphaProtozoan ProteinsActin cytoskeletonDevelopmentDictyosteliumPKCPLDQuorum sensing

Identifiers

PMID28257811
PMCPMC5480017
OpenAlexW2594440343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.