Evidence map›Paper›PMID 28257710›Full record

ArticleCell stem cell2017

Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

Guillaume Richard-Carpentier, Guy Sauvageau

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Guillaume Richard-CarpentierThe Leucegene Project at the Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3C 3J7, Canada; Banque de Cellules Leucémiques du Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada.
Guy SauvageauThe Leucegene Project at the Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3C 3J7, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Banque de Cellules Leucémiques du Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC H1T 2M4, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, QC H3T 1J4, Canada. Electronic address: guy.sauvageau@umontreal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.

Indexed as

Neoplastic Stem CellsAcute DiseaseHumansLeukemia, Myeloid, AcuteTranscriptome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.