ArticleAmerican journal of human genetics2017
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.
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Article in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 8 of them syntheses that pooled it.
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133citing papers in PubMed, 8 pooled it
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Who cites it
133 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus.Nature communications · 2025Pooled it
- Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.Nature genetics · 2025Pooled it
- ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.International journal of obesity (2005) · 2022Pooled it
- Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study.European journal of epidemiology · 2022Pooled it
- Pooled it
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.Nature genetics · 2019Pooled it
- A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors.Scientific reports · 2017Pooled it
- Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.Human molecular genetics · 2017Pooled it
- Depot-specific differences in visceral and subcutaneous adipose tissue from patients with obesity.Adipocyte · 2026Article
- Transferrin receptor 1-mediated iron uptake supports thermogenic activation in human cervical-derived adipocytes.FEBS letters · 2026Article
- Phosphomannomutase 1 restrains adipose thermogenic programming via inosine signaling.Molecular metabolism · 2026Article
- Disentangling adiposity-related and non-adiposity-related genetic pathways for type 2 diabetes.medRxiv : the preprint server for health sciences · 2026Article
- GANomics: bridging legacy and modern transcriptomic platforms for clinical applications.NPJ genomic medicine · 2026Article
- FastGxC: Fast and powerful context-specific eQTL mapping in bulk and single-cell data.Cell genomics · 2026Article
- Evaluating Cross-Platform Batch Correction Methods for Integrated Microarray and RNA-seq Data Analysis.bioRxiv : the preprint server for biology · 2026Article
- A conserved hormonal signalling-H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis.Nature metabolism · 2026Article
- Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease.Science advances · 2026Article
- Article
- Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Nature communications · 2026Article
- Integrated analysis of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters.The Journal of biological chemistry · 2026Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors.
Mete CivelekDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Calvin PanDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chelsea K RaulersonDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Arthur KoDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aiqing HeBristol-Myers Squibb, Pennington, NJ 08534, USA.
Charles TilfordBristol-Myers Squibb, Pennington, NJ 08534, USA.
Niyas K SaleemDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Christian FuchsbergerDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Narisu NarisuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Peter S ChinesNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, School of Medicine, King's College London, London SE1 7EH, UK.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Brian W ParksDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Päivi PajukantaDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Todd KirchgessnerBristol-Myers Squibb, Pennington, NJ 08534, USA.
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Peter S GargalovicBristol-Myers Squibb, Pennington, NJ 08534, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohlke@med.unc.edu.
Aldons J LusisDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jlusis@mednet.ucla.edu.
Funding
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANTOR, RITA M. · 1985 to 2019
$50.2MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MGenomics of dyslipidemia in MexicansR01HL095056 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAJUKANTA, PAIVI · 2009 to 2018
$5.9MUNC Predoc Training Progr in Bioinformatics/Comp BiologyT32GM067553 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELSTON, TIMOTHY C · 2005 to 2019
$2.5MFunctional genetic variants for type 2 diabetesU01DK105561 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2015 to 2019
$2.3MSystems Genetics Analysis of Gene-by-Environment Interactions in ObesityR00HL123021 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PARKS, BRIAN WESLEY · 2016 to 2018
$747kSystems genetics analysis of cardiometabolic trait loci in humans R00HL121172 · NHLBI · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE · 2016 to 2018
$741kIntramural NIH HHS Z01 HG000024Intramural NIH HHS ZIA HG000024Medical Research Council MR/J010642/1Medical Research Council MR/L01999X/1NHLBI NIH HHS F31 HL127921NHLBI NIH HHS P01 HL028481NHLBI NIH HHS R00 HL121172NHLBI NIH HHS R00 HL123021NHLBI NIH HHS R01 HL095056NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK105561NIGMS NIH HHS T32 GM067553
Abstract
Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We performed expression quantitative trait locus (eQTL) analyses by using abdominal subcutaneous adipose tissue of 770 extensively phenotyped participants of the METSIM study. We identified cis-eQTLs for 12,400 genes at a 1% false-discovery rate. Among an approximately 680 known genome-wide association study (GWAS) loci for cardio-metabolic traits, we identified 140 coincident cis-eQTLs at 109 GWAS loci, including 93 eQTLs not previously described. At 49 of these 140 eQTLs, gene expression was nominally associated (p < 0.05) with levels of the GWAS trait. The size of our dataset enabled identification of five loci associated (p < 5 × 10
Indexed as
Gene Expression RegulationQuantitative Trait LociAgedAnimalsCardiovascular DiseasesDatabases, GeneticGene Expression ProfilingGenome-Wide Association StudyGenotyping TechniquesHumansMaleMetabolic SyndromeMiceMiddle AgedNuclear ProteinsPhenotypeMHC class II transactivator proteinNuclear ProteinsTrans-Activators
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.