Evidence map›Paper›PMID 28257599›Full record

ArticleClinical and experimental immunology2017

Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis.

C R Grant, B S Holder, R Liberal, M A Heneghan, Y Ma, G Mieli-Vergani, D Vergani, M S Longhi

Open access · greenAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Can we cure autoimmune hepatitis?Current opinion in immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

C R GrantDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
B S HolderDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
R LiberalDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
M A HeneghanDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
Y MaDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
G Mieli-VerganiDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.
D Vergani
M S LonghiDepartment of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, London, UK.ORCID 0000-0002-4510-1249
King's College London · GBBeth Israel Deaconess Medical Center · USUniversidade do Porto · PT

Funding

Medical Research Council G0902288Medical Research Council MR/J006742/1
6 · The paper itself

Abstract

Autoimmune hepatitis (AIH) is characterized by overwhelming effector immune responses associated with defective regulatory T cells (T

Indexed as

AdolescentAdultCase-Control StudiesCell ProliferationChildCyclosporineFemaleHepatitis, AutoimmuneHumansImmunosuppressive AgentsInterferon-gammaKineticsMiddle AgedProgrammed Cell Death 1 ReceptorTacrolimusTh1 CellsCyclosporineIFNG protein, humanImmunosuppressive AgentsInterferon-gammaPDCD1 protein, humanProgrammed Cell Death 1 ReceptorTacrolimusautoimmune hepatitisco-inhibitory moleculeseffector T cellsimmunosuppressive drugsproinflammatory cytokines

Identifiers

PMID28257599
PMCPMC5461095
OpenAlexW2593447238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.