ArticlePloS one2017
Diagnostic features of quantitative comb-push shear elastography for breast lesion differentiation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Correlation of ultrasound bladder vibrometry assessment of bladder compliance with urodynamic study results.PloS one · 2017Trial
- Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach.Breast cancer research : BCR · 2023Article
- Ultrasound elastography evaluation of age-related muscle atrophy: AnProceedings of meetings on acoustics. Acoustical Society of America · 2023Article
- Hybrid high-definition microvessel imaging/shear wave elastography improves breast lesion characterization.Breast cancer research : BCR · 2022Article
- Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers.Ultrasound in medicine & biology · 2021Article
- Multi-parameter Sub-Hertz Analysis of Viscoelasticity With a Quality Metric for Differentiation of Breast Masses.Ultrasound in medicine & biology · 2020Article
- Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses.Breast (Edinburgh, Scotland) · 2020Article
- Ultrasound elastography using a regularized modified error in constitutive equations (MECE) approach: a comprehensive phantom study.Physics in medicine and biology · 2020Article
- Gap-filling method for suppressing grating lobes in ultrasound imaging: Experimental study with deep-learning approach.IEEE access : practical innovations, open solutions · 2020Article
- Monitoring Breast Cancer Response to Neoadjuvant Chemotherapy Using Ultrasound Strain Elastography.Translational oncology · 2019Article
- Evaluation of Reconstruction Parameters for 2-D Comb-Push Ultrasound Shear Wave Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- Production of acoustic radiation force using ultrasound: methods and applications.Expert review of medical devices · 2018Review
- Differentiation of Benign and Malignant Thyroid Nodules by Using Comb-push Ultrasound Shear Elastography: A Preliminary Two-plane View Study.Academic radiology · 2018Article
- A soft cervix, categorized by shear-wave elastography, in women with short or with normal cervical length at 18-24 weeks is associated with a higher prevalence of spontaneous preterm delivery.Journal of perinatal medicine · 2018Article
- Viscoelastic parameters as discriminators of breast masses: Initial human study results.PloS one · 2018Article
- Modified error in constitutive equations (MECE) approach for ultrasound elastography.The Journal of the Acoustical Society of America · 2017Article
- Mechanics Based Tomography: A Preliminary Feasibility Study.Sensors (Basel, Switzerland) · 2017Article
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Abstract
backgroundLesion stiffness measured by shear wave elastography has shown to effectively separate benign from malignant breast masses. The aim of this study was to evaluate different aspects of Comb-push Ultrasound Shear Elastography (CUSE) performance in differentiating breast masses.
methodsWith written signed informed consent, this HIPAA- compliant, IRB approved prospective study included patients from April 2014 through August 2016 with breast masses identified on conventional imaging. Data from 223 patients (19-85 years, mean 59.93±14.96 years) with 227 suspicious breast masses identifiable by ultrasound (mean size 1.83±2.45cm) were analyzed. CUSE was performed on all patients. Three regions of interest (ROI), 3 mm in diameter each, were selected inside the lesion on the B-mode ultrasound which also appeared in the corresponding shear wave map. Lesion elasticity values were measured in terms of the Young's modulus. In correlation to pathology results, statistical analyses were performed.
resultsPathology revealed 108 lesions as malignant and 115 lesions as benign. Additionally, 4 lesions (BI-RADS 2 and 3) were considered benign and were not biopsied. Average lesion stiffness measured by CUSE resulted in 84.26% sensitivity (91 of 108), 89.92% specificity (107 of 119), 85.6% positive predictive value, 89% negative predictive value and 0.91 area under the curve (P<0.0001). Stiffness maps showed spatial continuity such that maximum and average elasticity did not have significantly different results (P > 0.21).
conclusionCUSE was able to distinguish between benign and malignant breast masses with high sensitivity and specificity. Continuity of stiffness maps allowed for choosing multiple quantification ROIs which covered large areas of lesions and resulted in similar diagnostic performance based on average and maximum elasticity. The overall results of this study, highlights the clinical value of CUSE in differentiation of breast masses based on their stiffness.
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