ArticlePloS one2017
High-speed adaptive optics line scan confocal retinal imaging for human eye.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023Review
- Adaptive optics wavefront correction using a damped transpose matrix of the influence function.Photonics research · 2022Article
- Hybrid FPGA-CPU pupil tracker.Biomedical optics express · 2021Article
- Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure.Translational vision science & technology · 2021Article
- Virtually structured detection enables super-resolution ophthalmoscopy of rod and cone photoreceptors in human retina.Quantitative imaging in medicine and surgery · 2021Article
- Template free eye motion correction for scanning systems.Optics letters · 2021Article
- Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia.Translational vision science & technology · 2021Article
- Correcting intra-volume distortion for AO-OCT using 3D correlation based registration.Optics express · 2020Article
- Investigation of confocal microscopy for differentiation of renal cell carcinoma versus benign tissue. Can an optical biopsy be performed?Asian journal of urology · 2020Article
- Volumetric fluorescein angiography (vFA) by oblique scanning laser ophthalmoscopy in mouse retina at 200 B-scans per second.Biomedical optics express · 2019Article
- Near infrared adaptive optics flood illumination retinal angiography.Biomedical optics express · 2019Article
- NoninvasiveBiomedical optics express · 2018Article
- High speed adaptive optics ophthalmoscopy with an anamorphic point spread function.Optics express · 2018Article
- Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.Investigative ophthalmology & visual science · 2017Review
- Adaptive optics scanning laser ophthalmoscopy in fundus imaging, a review and update.International journal of ophthalmology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeContinuous and rapid eye movement causes significant intraframe distortion in adaptive optics high resolution retinal imaging. To minimize this artifact, we developed a high speed adaptive optics line scan confocal retinal imaging system.
methodsA high speed line camera was employed to acquire retinal image and custom adaptive optics was developed to compensate the wave aberration of the human eye's optics. The spatial resolution and signal to noise ratio were assessed in model eye and in living human eye. The improvement of imaging fidelity was estimated by reduction of intra-frame distortion of retinal images acquired in the living human eyes with frame rates at 30 frames/second (FPS), 100 FPS, and 200 FPS.
resultsThe device produced retinal image with cellular level resolution at 200 FPS with a digitization of 512×512 pixels/frame in the living human eye. Cone photoreceptors in the central fovea and rod photoreceptors near the fovea were resolved in three human subjects in normal chorioretinal health. Compared with retinal images acquired at 30 FPS, the intra-frame distortion in images taken at 200 FPS was reduced by 50.9% to 79.7%.
conclusionsWe demonstrated the feasibility of acquiring high resolution retinal images in the living human eye at a speed that minimizes retinal motion artifact. This device may facilitate research involving subjects with nystagmus or unsteady fixation due to central vision loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.