ArticlePLoS neglected tropical diseases2017
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015).
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Dual seasonal pattern for hemorrhagic fever with renal syndrome and its potential determinants in China.The Science of the total environment · 2023Pooled it
- Soil characteristics associated with historical commensal rodent plague foci in Yunnan Province, China.Frontiers in veterinary science · 2026Article
- Abundance and Infestation of Mites on Bower's White-Toothed Rat (Veterinary sciences · 2025Article
- The 2016 Severe Floods and Incidence of Hemorrhagic Fever With Renal Syndrome in the Yangtze River Basin.JAMA network open · 2024Article
- Relationship Between Climate Change and Marmot Plague ofChina CDC weekly · 2024Article
- Status and analysis of undetected plague cases in Yunnan Province, China.Frontiers in public health · 2024Article
- The complex genomic diversity ofEcology and evolution · 2023Article
- Climate-driven marmot-plague dynamics in Mongolia and China.Scientific reports · 2023Article
- Update on Novel Taxa and Revised Taxonomic Status of Bacteria Isolated from Nondomestic Animals Described in 2018 to 2021.Journal of clinical microbiology · 2023Review
- Epidemiological Characteristics of Human and Animal Plague in Yunnan Province, China, 1950 to 2020.Microbiology spectrum · 2022Article
- Anaplasma phagocytophilum in Marmota himalayana.BMC genomics · 2022Article
- Article
- Serological investigation of plague and brucellosis infection inFrontiers in public health · 2022Article
- First Case Report of Human Plague Caused by Excavation, Skinning, and Eating of a Hibernating Marmot (Frontiers in public health · 2022Article
- Distribution and Characteristics of Human Plague Cases and Yersinia pestis Isolates from 4 Marmota Plague Foci, China, 1950-2019.Emerging infectious diseases · 2021Review
- A LyticFrontiers in cellular and infection microbiology · 2021Article
- First detection of the kdr mutation (L1014F) in the plague vector Xenopsylla cheopis (Siphonaptera: Pulicidae).Parasites & vectors · 2019Article
- Vaccines for emerging pathogens: prospects for licensure.Clinical and experimental immunology · 2019Review
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlague, a Yersinia pestis infection, is a fatal disease with tremendous transmission capacity. However, the mechanism of how the pathogen stays in a reservoir, circulates and then re-emerges is an enigma. METHODOLOGY/PRINCIPAL
findingsWe studied a plague outbreak caused by the construction of a large reservoir in southwest China followed 16-years' surveillance. CONCLUSIONS/SIGNIFICANCE: The results show the prevalence of plague within the natural plague focus is closely related to the stability of local ecology. Before and during the decade of construction the reservoir on the Nanpan River, no confirmed plague has ever emerged. With the impoundment of reservoir and destruction of drowned farmland and vegetation, the infected rodent population previously dispersed was concentrated together in a flood-free area and turned a rest focus alive. Human plague broke out after the enzootic plague via the flea bite. With the construction completed and ecology gradually of human residential environment, animal population and type of vegetation settling down to a new balance, the natural plague foci returned to a rest period. With the rodent density decreased as some of them died, the flea density increased as the rodents lived near or in local farm houses where had more domestic animals, and human has a more concentrated population. In contrast, in the Himalayan marmot foci of the Qinghai-Tibet Plateau in the Qilian Mountains. There are few human inhabitants and the local ecology is relatively stable; plague is prevalence, showing no rest period. Thus the plague can be significantly affected by ecological shifts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.